Patient- and Trial-Specific Barriers to Participation in Cardiovascular Randomized Clinical Trials

The purpose of this study was to quantitatively examine the association of patient- and trial-specific factors with participation in cardiovascular randomized clinical trials. Randomized clinical trials are central to evidenced-based medicine, but low patient participation rates and potentially modifiable barriers are not well understood. At a large U.S. academic health system, we examined screening logs from December 1, 2005, to February 28,...