Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways

Our previous studies have demonstrated that ginsenoside Rg1 is a novel class of potent phytoestrogen and can mimic the action of estradiol in stimulation of MCF‐7 cell growth by the crosstalk between insulin‐like growth factor‐I receptor (IGF‐IR)‐dependent pathway and estrogen receptor (ER)‐dependent pathway. The present study was designed to investigate the neuroprotective effects of ginsenoside Rg1 against 6‐hydroxydopamine (6‐OHDA)‐induced...