Man Sau Wong
Hong Kong Polytechnic University
EndocrinologyBone remodelingReceptorChemistryIn vivoOsteoporosisBone mineralEstrogenOsteoblastGenisteinRANKLParathyroid hormoneCalciumSignal transductionMedicineOvariectomized ratEstrogen receptorBiologyCell biologyPharmacology
187Publications
35H-index
3,416Citations
Publications 160
Newest
#1Liping Zhou (PolyU: Hong Kong Polytechnic University)H-Index: 5
#2Christina Chui-Wa Poon (PolyU: Hong Kong Polytechnic University)H-Index: 1
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
view all 7 authors...
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#1Liping Zhou (PolyU: Hong Kong Polytechnic University)H-Index: 5
#2Ka-Ying Wong (PolyU: Hong Kong Polytechnic University)H-Index: 2
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
view all 8 authors...
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#1Jia-Li Zhang (SHU: Shanghai University)H-Index: 1
#2Wen-Xiong Li (SHU: Shanghai University)H-Index: 1
Last. Yan Zhang (SHU: Shanghai University)H-Index: 26
view all 6 authors...
Abstract Background : Coronavirus disease-2019 (COVID-19) caused by infection with severe acute respiratory coronavirus-2 (SARS-CoV-2) has been spreading rapidly throughout China and in other countries since the end of 2019. The World Health Organization (WHO) has declared that the epidemic is a public health emergency of international concerns. The timely and appropriate measures for treating COVID-19 in China, which are inseparable from the contribution of traditional Chinese medicine (TCM), h...
3 CitationsSource
#1Zuo-cheng Qiu (JNU: Jinan University)H-Index: 1
#2Yan Zhang (SHU: Shanghai University)H-Index: 26
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
view all 9 authors...
Abstract 8-prenylgenistein (8PG) was previously reported to exert stronger osteogenic activity than genistein, a well-known soy phytoestrogen. However, the molecular mechanism underlying the actions of 8PG on osteoblasts was far from clear. In the present study, the osteogenic effects and mechanisms of 8PG and genistein were studied using human BMSC and murine pre-osteoblast MC3T3-E1 cells. Our results indicated that the stimulatory effects of 8PG and genistein on osteoblast differentiation were...
2 CitationsSource
#1Wai Yin PangH-Index: 3
#2Xin Lun WangH-Index: 3
Last. Man Sau WongH-Index: 35
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Rhizoma Drynaria (RD) has been widely used for healing bone fractures or related diseases in traditional Chinese medicine. The present study was designed to determine if RD flavonoids (RDTF) could cxert estrogen-like protective actions on bone, Young C57/BL6J mice were ovariectomized (OVX) and treated orally with RDTF (0.087. 0.173 0.346 mg/g/day). 17s-estradiol (2 μg/g/day) or its vehicle for 6 weeks. Bone mineral densities (BMD) was measured by periphcral quantitative computed tomography (pQCT...
3 CitationsSource
#1Xi-yang Tang (JNU: Jinan University)H-Index: 3
#2Meng-xue Gao (JNU: Jinan University)H-Index: 2
Last. Xin-Sheng Yao (SPU: Shenyang Pharmaceutical University)H-Index: 32
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Xian-Ling-Gu-Bao (XLGB), a famous traditional Chinese medicine prescription consisted of six herbal medicines, was used for prevention and treatment of osteoporosis in China. As an oral formulation, the multiple components contained in XLGB were inevitably biotransformed by the intestinal microflora before absorption via the gastrointestinal tract. However, the dynamic profiles of biotransformation products of XLGB remain unknown. In this paper, a rapid and sensitive ultra-performance liquid chr...
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#1Hui Hui Xiao (PolyU: Hong Kong Polytechnic University)H-Index: 6
#2Quan Gui Gao (PolyU: Hong Kong Polytechnic University)H-Index: 6
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
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#1Xiao-Li Dong (PolyU: Hong Kong Polytechnic University)H-Index: 11
#2Wen Xuan Yu (PolyU: Hong Kong Polytechnic University)H-Index: 2
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
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Oxidative stress (OS) is the common mechanism for age-related diseases. The co-occurrence of osteoporosis (OP) and cardiovascular disease (CVD) in postmenopausal women makes it warranted to find a holistic approach for treatment of multiple diseases or conditions. The rhizome of Ligusticum chuanxiong Hort. (CX), which has high anti-oxidant properties and is widely used for CVD treatment in China, might be the potential candidate. In the present study, CX ethanol extract (CXE) was applied to H2O2...
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#1Liping Zhou (PolyU: Hong Kong Polytechnic University)H-Index: 5
#2Christina Chui-Wa Poon (PolyU: Hong Kong Polytechnic University)H-Index: 1
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
view all 9 authors...
Icariin, a flavonoid phytoestrogen derived from Herba epimedii, has been reported to exert estrogenic effects in bone and activate phosphorylation of estrogen receptor (ER) alpha in osteoblastic cells. However, it is unclear whether icariin selectively exerts estrogenic activities in bone without inducing undesirable effects in other estrogen-sensitive tissues. The present study aimed to investigate the tissue-selective estrogenic activities of icariin in estrogen-sensitive tissues in vivo and i...
2 CitationsSource
#1Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
#2Chui Wa Christina Poon (PolyU: Hong Kong Polytechnic University)
Last. Hui-Hui Xiao (PolyU: Hong Kong Polytechnic University)H-Index: 4
view all 4 authors...
Demands for natural products, in the form of botanicals, dietary supplements, and herbal medicine, for management of chronic diseases are increasing globally. Natural products might be an alternative for the management of bone health to meet the demands of a growing aging population. Different types of natural products, including Chinese herbal medicine decoctions, herbs, and isolated phytochemicals, have been demonstrated to exert bone protective effects. The most common types of bone protectiv...
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