Journal of Neurochemistry
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#1Samuel T. Slocum (UNC: University of North Carolina at Chapel Hill)H-Index: 9
#2Jeffrey F. DiBerto (UNC: University of North Carolina at Chapel Hill)H-Index: 16
Last. Bryan L. Roth (UNC: University of North Carolina at Chapel Hill)H-Index: 129
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A confluence of factors has renewed interest in the scientific understanding and translational potential of psychedelic drugs such as lysergic acid diethylamide (LSD), mescaline, and psilocybin: the desire for additional approaches to mental health care, incremental progress in basic and clinical research, and the reconsideration and relaxation of existing drug policies. With the United States Food and Drug Administration's designation of psilocybin as a "Breakthrough Therapy" for treatment-resi...
#1Tao Ma (Wake Forest University)H-Index: 26
Understanding the molecular signaling mechanisms underlying cognition and neuronal plasticity would provide insights into the pathogenesis of neuronal disorders characterized with cognitive syndromes such as Alzheimer's disease (AD). Phosphorylation of the mRNA translational factor eukaryotic elongation factor 2 (eEF2) by its specific kinase eEF2K is critically involved in protein synthesis regulation. In this review, we discussed recent studies on the roles of eEF2K/eEF2 signaling in the contex...
#1Alaina M. Jaster (VCU: Virginia Commonwealth University)H-Index: 2
#2Mario de la Fuente Revenga (VCU: Virginia Commonwealth University)H-Index: 13
Last. Javier González-Maeso (VCU: Virginia Commonwealth University)H-Index: 39
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Psychedelic research across different disciplines and biological levels is growing at a remarkably fast pace. In the prospect of a psychedelic drug becoming again an approved treatment, much of these efforts have been oriented toward exploring the relationship between the actual psychedelic effects and those manifestations of therapeutic interest. Considering the central role of the serotonin 5-HT2A receptor in the distinct effects of psychedelics in human psyche, neuropharmacology sits at the c...
#1Mackenzie E. Smith (U of T: University of Toronto)
#2Giulia Cisbani (U of T: University of Toronto)H-Index: 5
Last. Richard P. Bazinet (U of T: University of Toronto)H-Index: 56
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Previously, results from studies investigating if brain palmitic acid (16:0; PAM) was maintained by either dietary uptake or lipogenesis de novo (DNL) varied. Here, we utilize naturally occurring carbon isotope ratios (13 C/12 C; δ13 C) to uncover the origin of brain PAM. Additionally, we explored brain and liver fatty acid concentration, total brain metabolomic profile, and behaviour. BALB/c dams were equilibrated onto either a low PAM diet (LP; null 95%) prior to producing one generation of of...
#1Martyna M. Matuszyk (University of Sheffield)H-Index: 2
#2Claire J. Garwood (University of Sheffield)H-Index: 19
Last. Stephen B. Wharton (University of Sheffield)H-Index: 58
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Although controversial, the amyloid cascade hypothesis remains central to the Alzheimer’s disease (AD) field and posits amyloid- beta (Aβ) as the central factor initiating disease onset. In recent years, there has been an increase in emphasis on studying the role of low molecular weight aggregates, such as oligomers, which are suggested to be more neurotoxic than fibrillary Aβ. Other Aβ isoforms, such as truncated Aβ, have also been implicated in disease. However, developing a clear understandin...
#1Zhaoke Luo (Fujian Medical University)
#2Xinyue Liao (Fujian Medical University)
Last. Daoshu Luo (Fujian Medical University)H-Index: 9
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Trigeminal neuralgia (TN) is a type of severe paroxysmal neuropathic pain commonly triggered by mild mechanical stimulation in the orofacial area. Piezo2, a mechanically gated ion channel that mediates tactile allodynia in neuropathic pain, can be potentiated by a cyclic adenosine monophosphate (cAMP)-dependent signaling pathway that involves the exchange protein directly activated by cAMP 1 (Epac1). To study whether Piezo2-mediated mechanotransduction contributes to peripheral sensitization in ...
#1Zhang Huiliang (HUST: Huazhong University of Science and Technology)
#2Yang Mengzhe (HUST: Huazhong University of Science and Technology)
Last. Liu Rong (HUST: Huazhong University of Science and Technology)
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Reactive astrogliosis is an early event in Alzheimer's disease (AD) brain and plays a key role in synaptic degeneration in AD development. Zinc accumulates in extracellular fraction and synaptosomes in AD human brains with its effect on reactive astrocytes remaining unknown. Through Western blotting, Quantitative polymerase chain reaction (qPCR), and immunofluorescence detection on primary astrocytes treated by zinc and/or zinc chelator, we revealed that zinc induced harmful A1-type reactive ast...
#1Arsalan Yousuf (Illawarra Health & Medical Research Institute)H-Index: 7
#2Xiaosa Wu (UQ: University of Queensland)H-Index: 4
Last. David J. Adams (Illawarra Health & Medical Research Institute)H-Index: 110
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αO-Conotoxin GeXIVA is a 28 amino acid peptide derived from the venom of the marine snail Conus generalis. The presence of four cysteine residues in the structure of GeXIVA allows it to have three different disulfide isomers, that is, the globular, ribbon or bead isomer. All three isomers are active at α9α10 nicotinic acetylcholine receptors, with the bead isomer, GeXIVA[1,2], being the most potent and exhibiting analgesic activity in animal models of neuropathic pain. The original report of GeX...
#1Ming Yang (Yunnan University)
#2Yiyi Chen (University of Tübingen)H-Index: 2
Last. François Paquet-Durand (University of Tübingen)H-Index: 29
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The retina has the highest relative energy consumption of any tissue, depending on a steady supply of glucose from the bloodstream. Glucose uptake is mediated by specific transporters whose regulation and expression are critical for the pathogenesis of many diseases, including diabetes and diabetic retinopathy. Here, we used immunofluorescence to show that glucose transporter-2 (GLUT2) is expressed in horizontal cells of the mouse neuroretina in proximity to inner retinal capillaries. To study t...
#1Aurora Savino (UNITO: University of Turin)H-Index: 8
#2Charles D. Nichols (LSU Health Sciences Center New Orleans)H-Index: 29
Psychedelic drugs are gaining attention from the scientific community as potential new compounds for the treatment of psychiatric diseases such as mood and substance use disorders. The 5-HT2A receptor has been identified as the main molecular target, and early studies pointed to an effect on the expression of neuroplasticity genes. Analysing RNA-seq data from the prefrontal cortex of rats chronically treated with lysergic acid diethylamide (LSD), we describe the psychedelic-induced rewiring of g...
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