How do K-RAS-activated cells evade cellular defense mechanisms?
Abstract
Lung adenocarcinomas, like other cancers, develop through the accumulation of epigenetic and genetic alterations. Numerous studies have shown that K-RAS mutation is among the most important early events in carcinogenesis of the lung. However, it is also well established that growth-stimulating signals feed back into growth-suppressing pathways, and any imbalance in these signaling networks will cause the cell to exit the cell cycle, thereby...
Paper Details
Title
How do K-RAS-activated cells evade cellular defense mechanisms?
Published Date
May 11, 2015
Journal
Volume
35
Issue
7
Pages
827 - 832
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