Review paper
CDK4 and CDK6 kinases: From basic science to cancer therapy
Abstract
Targeting cyclin-dependent kinases Cyclin-dependent kinases (CDKs), in complex with their cyclin partners, modulate the transition through phases of the cell division cycle. Cyclin D–CDK complexes are important in cancer progression, especially for certain types of breast cancer. Fassl et al . discuss advances in understanding the biology of cyclin D–CDK complexes that have led to new concepts about how drugs that target these complexes induce...
Paper Details
Title
CDK4 and CDK6 kinases: From basic science to cancer therapy
Published Date
Jan 14, 2022
Journal
Volume
375
Issue
6577