#1Richard Stone(HHMI: Howard Hughes Medical Institute)H-Index: 2
Many Afghan scholars are trying to leave their country after the Taliban seized power earlier this month. They fear a return to the Taliban9s harsh regime between 1996 and 2001, when women were deprived of civil liberties and intellectuals and others opposed to its ideology summarily executed. Taliban leaders insist they have moderated their views, but few Afghans take those reassurances at face value and many say the group9s philosophy is inimical to science. As Science went to press, European ...
September marks the 30th anniversary of the beginning of the 2-year Biosphere 2 closed habitat experiment. While that experiment9s scientific findings have been overshadowed by high-profile crew conflicts and technological failures, a more modest attempt to simulate a Martian habitat is just beginning inside a test module originally built for Biosphere 2. The researchers behind the Space Analog for the Moon and Mars (SAM) aim to have a smaller, hermetically sealed system in which scientists can ...
As the extraordinarily infectious Delta variant of SARS-CoV-2 continues to spread around the world, vaccines9 powers are showing their limits. Although they are still extremely effective at preventing severe COVID-19, the tantalizing hope that the shots could block almost all infections—and squelch transmission—has evaporated. That has upended return to office and school plans, threatened economic recoveries, and spurred fresh political rows over mask and vaccination mandates. Now, amid new stud...
From ancient texts to apps that ask users to rate their hourly happiness level to the multibillion-dollar wellness industry, the hunt for happiness seems to be universal. And yet it remains as elusive as it is mundane. Two new exhibitions at the Wellcome Collection—Joy and Tranquility—offer an unconventional perspective on the types of things that make us feel good.
Last. Guangshuo Ou(THU: Tsinghua University)H-Index: 27
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Protein kinase activity must be precisely regulated, but how a cell governs hyperactive kinases remains unclear. In this study, we generated a constitutively active mitogen-activated protein kinase DYF-5 (DYF-5CA) in Caenorhabditis elegans that disrupted sensory cilia. Genetic suppressor screens identified that mutations of ADR-2, an RNA adenosine deaminase, rescued ciliary phenotypes of dyf-5CA We found that dyf-5CA animals abnormally transcribed antisense RNAs that pair with dyf-5CA messenger ...
This week, the US Food and Drug Administration (FDA) granted full approval to the Pfizer-BioNTech coronavirus vaccine for individuals 16 years and older. This milestone decision, the first full approval of a vaccine for COVID-19, will almost certainly clear a path for businesses, hospitals, and government agencies that have not already done so to adopt vaccine mandates for their employees. For colleges and universities that have been on the fence about requiring the vaccine, the FDA’s decision m...
The antitumor efficacy of cancer immunotherapy can correlate with the presence of certain bacterial species within the gut microbiome. However, many of the molecular mechanisms that influence host response to immunotherapy remain elusive. In this study, we show that members of the bacterial genus Enterococcus improve checkpoint inhibitor immunotherapy in mouse tumor models. Active enterococci express and secrete orthologs of the NlpC/p60 peptidoglycan hydrolase SagA that generate immune-active m...