Review paper
p53 signaling in cancer progression and therapy
Abstract
The p53 protein is a transcription factor known as the "guardian of the genome" because of its critical function in preserving genomic integrity. The TP53 gene is mutated in approximately half of all human malignancies, including those of the breast, colon, lung, liver, prostate, bladder, and skin. When DNA damage occurs, the TP53 gene on human chromosome 17 stops the cell cycle. If p53 protein is mutated, the cell cycle is unrestricted and the...
Paper Details
Title
p53 signaling in cancer progression and therapy
Published Date
Dec 1, 2021
Journal
Volume
21
Issue
1