Cancer Cell International
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5.72
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1 page of 272 pages (2,715 results)
Newest
#1R. Daniel Bonfil (NSU: Nova Southeastern University)H-Index: 2
#2Wei Chen (WSU: Wayne State University)H-Index: 23
Last. Rafael Fridman (WSU: Wayne State University)H-Index: 60
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BACKGROUND The Discoidin Domain Receptor 1 (DDR1) is one of the two members of a unique family of receptor tyrosine kinase receptors that signal in response to collagen, which has been implicated in cancer progression. Here, we examined the expression of DDR1 in prostate cancer (PCa), and assessed its potential value as a prognostic marker, as a function of grade, stage and other clinicopathologic parameters. METHODS We investigated the association between the expression level and subcellular lo...
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#1Jialu Guo (ZJNU: Zhejiang Chinese Medical University)H-Index: 2
#2Jianfeng Zheng (Nanjing Medical University)
Last. Jinyi Tong (ZJNU: Zhejiang Chinese Medical University)H-Index: 1
view all 4 authors...
N6-methyladenosine (m6A) is the most abundant RNA modification of mammalian mRNAs and plays a vital role in many diseases, especially tumours. In recent years, m6A has become the topic of intense discussion in epigenetics. M6A modification is dynamically regulated by methyltransferases, demethylases and RNA-binding proteins. Ovarian cancer (OC) is a common but highly fatal malignancy in female. Increasing evidence shows that changes in m6A levels and the dysregulation of m6A regulators are assoc...
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#1Yu-Jie Xu (SYSU: Sun Yat-sen University)H-Index: 1
#2Min-Ke He (SYSU: Sun Yat-sen University)H-Index: 6
Last. Ming Shi (SYSU: Sun Yat-sen University)H-Index: 29
view all 7 authors...
BACKGROUND The accumulation of single nucleotide variants (SNVs) and the emergence of neoantigens can affect tumour proliferation and the immune microenvironment. However, the SNV-related immune microenvironment characteristics and key genes involved in hepatocellular carcinoma (HCC) are still unclear. We aimed to evaluate differences in the SNV-related immune microenvironment, construct a prognostic model and validate the key genes in vitro. METHODS The categories of samples were defined by the...
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#1Ya-Nan Jin (SYSU: Sun Yat-sen University)H-Index: 4
#2Meng-Yun Qiang (CAS: Chinese Academy of Sciences)
Last. Liang-Ping Xia (SYSU: Sun Yat-sen University)
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BACKGROUND We aimed to comprehensively investigate the optimal cumulative cisplatin dose during concurrent chemoradiotherapy (CC-CCD) for locoregionally advanced nasopharyngeal carcinoma (CA-LANPC) with different tumor responses after neoadjuvant chemotherapy (NAC). METHODS Patients with CA-LANPC who underwent NAC followed by cisplatin-based concurrent chemoradiotherapy were retrospectively analyzed. Evaluation of tumor response in patients was conducted by Response Evaluation Criteria for Solid...
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#1Jing Lv (Qingdao University)H-Index: 10
Last. Manming Cao (Southern Medical University)
view all 6 authors...
Background null Gastric cancer (GC) is a common malignancy of the digestive system. Antioxidant activity is regarded as a possible mechanism in ectopic cancer. Hence, oxidative stress regulation is being evaluated for cancer treatment. Previous research has demonstrated that Nestin is associated with antioxidative resistance via its modulation of the Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. null Methods null We determined the role of...
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#1Shuangya Deng (CSU: Central South University)
#2Lun Li (CSU: Central South University)
Last. Tong Han (CSU: Central South University)
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BACKGROUND The high potential for tumor recurrence and chemoresistance is a major challenge of clinical gastric cancer treatment. Increasing evidence suggests that the presence of tumor initiating cells (TICs) is the principal cause of tumor recurrence and chemoresistance. However, the underlying mechanism of TIC development remains controversial. METHODS To identify novel molecular pathways in gastric cancer, we screened the genomic expression profile of 155 gastric cancer patients from the TCG...
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#1Fei Gao (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 9
#2Meisi Lin (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 2
Last. Qiyan Chen (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 2
view all 8 authors...
BACKGROUND High-dose melphalan (HDMEL, 200 mg/m2) is considered as the standard conditioning regimen for autologous hematopoietic stem cell transplantation (auto-HSCT) in multiple myeloma (MM). However, whether the combination of melphalan with busulfan (BUMEL) conditioning outperforms HDMEL remains controversy. Accordingly, a systematic review and meta-analysis was carried out to compare the outcomes of HDMEL and BUMEL-based conditioning regimens in newly diagnosed MM patients having undergone ...
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#1Jiang Y (Boston Children's Hospital)H-Index: 1
#2Shui-yan Wu (Soochow University (Suzhou))H-Index: 2
Last. Di Wu (Boston Children's Hospital)
view all 26 authors...
Background null Acute myeloid leukemia (AML) is a myeloid neoplasm accounts for 7.6% of hematopoietic malignancies. AML is a complex disease, and understanding its pathophysiology is contributing to the improvement in the treatment and prognosis of AML. In this study, we assessed the expression profile and molecular functions of CCAAT enhancer binding protein gamma (CEBPG), a gene implicated in myeloid differentiation and AML progression. null Methods null shRNA mediated gene interference was us...
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#2Hang Tong (CQMU: Chongqing Medical University)H-Index: 5
#3Hubin Yin (CQMU: Chongqing Medical University)H-Index: 9
Last. Weiyang He (CQMU: Chongqing Medical University)H-Index: 16
view all 0 authors...
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#1Zhipeng Jiang (SYSU: Sun Yat-sen University)H-Index: 8
#2Hao Hu (SYSU: Sun Yat-sen University)
Last. Shuang Chen (SYSU: Sun Yat-sen University)H-Index: 8
view all 8 authors...
AIM Previous studies have reported that circular RNA (circRNA) is associated with the pathogenesis of CRC. This study was designed to reveal the mechanism of circ-ring finger protein 121 (circ-RNF121) in colorectal cancer (CRC). MATERIALS AND METHODS The levels of circ-RNF121, microRNA-1224-5p (miR-1224-5p) and forkhead box M1 (FOXM1) were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Protein level was detected by western blot. Cell proliferation was analyzed by 3-(4,...
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