Original paper
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients
Abstract
Immune checkpoint inhibitor (ICI) therapy continues to revolutionize melanoma treatment, but only a subset of patients respond. Major efforts are underway to develop minimally invasive predictive assays of ICI response. Using single-cell transcriptomics, we discovered a unique CD8 T cell blood/tumor-shared subpopulation in melanoma patients with high levels of oxidative phosphorylation (OXPHOS), the ectonucleotidases CD38 and CD39, and both...
Paper Details
Title
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients
Published Date
Nov 22, 2021
Volume
219
Issue
1
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Notes
History