Journal of Experimental Medicine
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#1Chun-Chin Chen (Cornell University)
#2Bo-Ruei Chen (UAB: University of Alabama at Birmingham)
Last. Barry P. Sleckman (UAB: University of Alabama at Birmingham)H-Index: 57
view all 17 authors...
A whole-genome CRISPR/Cas9 screen identified ATP2A2, the gene encoding the Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 2 protein, as being important for V(D)J recombination. SERCAs are ER transmembrane proteins that pump Ca2+ from the cytosol into the ER lumen to maintain the ER Ca2+ reservoir and regulate cytosolic Ca2+-dependent processes. In preB cells, loss of SERCA2 leads to reduced V(D)J recombination kinetics due to diminished RAG-mediated DNA cleavage. SERCA2 deficiency in B cells le...
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#1Siyu Pei (CAS: Chinese Academy of Sciences)H-Index: 3
#2Mingzhu Huang (Fudan University)H-Index: 3
Last. Yichuan Xiao (CAS: Chinese Academy of Sciences)H-Index: 27
view all 22 authors...
TGFβ is essential for the generation of anti-tumor Th9 cells; on the other hand, it causes resistance against anti-tumor immunity. Despite recent progress, the underlying mechanism reconciling the double-edged effect of TGFβ signaling in Th9-mediated cancer immunotherapy remains elusive. Here, we find that TGFβ-induced down-regulation of bifunctional apoptosis regulator (BFAR) represents the key mechanism preventing the sustained activation of TGFβ signaling and thus impairing Th9 inducibility. ...
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#1Chase D. McCann (Cornell University)H-Index: 7
#2Christiaan H. van Dorp (LANL: Los Alamos National Laboratory)H-Index: 5
Last. R. Brad Jones (Cornell University)H-Index: 27
view all 19 authors...
HIV-specific CD8+ T cells partially control viral replication and delay disease progression, but they rarely provide lasting protection, largely due to immune escape. Here, we show that engrafting mice with memory CD4+ T cells from HIV+ donors uniquely allows for the in vivo evaluation of autologous T cell responses while avoiding graft-versus-host disease and the need for human fetal tissues that limit other models. Treating HIV-infected mice with clinically relevant HIV-specific T cell product...
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#1Xiaoying Zhou (Stanford University)H-Index: 4
#2Wong Yu (Stanford University)H-Index: 6
Last. Kari C. Nadeau (Stanford University)H-Index: 74
view all 8 authors...
Food allergies are a leading cause of anaphylaxis, and cellular mechanisms involving antigen presentation likely play key roles in their pathogenesis. However, little is known about the response of specific antigen-presenting cell (APC) subsets to food allergens in the setting of food allergies. Here, we show that in peanut-allergic humans, peanut allergen drives the differentiation of CD209+ monocyte-derived dendritic cells (DCs) and CD23+ (FcєRII) myeloid dendritic cells through the action of ...
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#1Jan Rossaint (WWU: University of Münster)H-Index: 21
#2Katharina Thomas (WWU: University of Münster)H-Index: 2
Last. Alexander Zarbock (WWU: University of Münster)H-Index: 67
view all 12 authors...
Beyond hemostasis, platelets actively participate in immune cell recruitment and host defense, yet their potential in the resolution of inflammatory processes remains unknown. Here, we demonstrate that platelets are recruited into the lung together with neutrophils during the onset of inflammation and alongside regulatory T (T reg) cells during the resolution phase. This partnering dichotomy is regulated by differential adhesion molecule expression during resolution. Mechanistically, intravascul...
1 CitationsSource
#1Rachel N. Cotton (Harvard University)H-Index: 8
#2Marcin Wegrecki (Monash University, Clayton campus)H-Index: 4
Last. D. Branch Moody (Brigham and Women's Hospital)H-Index: 61
view all 18 authors...
We optimized lipidomics methods to broadly detect endogenous lipids bound to cellular CD1a proteins. Whereas membrane phospholipids dominate in cells, CD1a preferentially captured sphingolipids, especially a C42, doubly unsaturated sphingomyelin (42:2 SM). The natural 42:2 SM but not the more common 34:1 SM blocked CD1a tetramer binding to T cells in all human subjects tested. Thus, cellular CD1a selectively captures a particular endogenous lipid that broadly blocks its binding to TCRs. Crystal ...
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#1Laura Solforosi (Janssen Pharmaceutica)H-Index: 5
#2Harmjan Kuipers (Janssen Pharmaceutica)H-Index: 3
Last. Roland Zahn (Janssen Pharmaceutica)H-Index: 20
view all 43 authors...
Safe and effective coronavirus disease-19 (COVID-19) vaccines are urgently needed to control the ongoing pandemic. While single-dose vaccine regimens would provide multiple advantages, two doses may improve the magnitude and durability of immunity and protective efficacy. We assessed one- and two-dose regimens of the Ad26.COV2.S vaccine candidate in adult and aged nonhuman primates (NHPs). A two-dose Ad26.COV2.S regimen induced higher peak binding and neutralizing antibody responses compared wit...
2 CitationsSource
#1Rick Kapur (UvA: University of Amsterdam)H-Index: 23
#2John W. Semple (Lund University)H-Index: 48
Platelets convey important nonhemostatic immune functions; however, their potential role in resolving pulmonary inflammation remains to be determined. In this issue of JEM, Rossaint et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201353) reveal that platelets contribute to the resolution of pulmonary inflammation by directly recruiting T regulatory (T reg) cells to the lungs and by transcriptionally reprogramming alveolar macrophages toward an anti-inflammatory phenotype.
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#1Paul Bastard (French Institute of Health and Medical Research)H-Index: 9
#2Elizaveta OrlovaH-Index: 5
Last. Michail S. Lionakis (NIH: National Institutes of Health)H-Index: 46
view all 65 authors...
Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account for at least 10% of cases of life-threatening COVID-19 pneumonia in the general population. We report 22 APS-1 patients from 21 kindreds in seven countries, aged between 8 and 48 yr and infected with ...
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#1Jorge Arasa (ETH Zurich)H-Index: 1
#2Victor Collado-Diaz (ETH Zurich)H-Index: 5
Last. Cornelia Halin (ETH Zurich)H-Index: 32
view all 17 authors...
Dendritic cell (DC) migration to draining lymph nodes (dLNs) is a slow process that is believed to begin with DCs approaching and entering into afferent lymphatic capillaries. From capillaries, DCs slowly crawl into lymphatic collectors, where lymph flow induced by collector contraction supports DC detachment and thereafter rapid, passive transport to dLNs. Performing a transcriptomics analysis of dermal endothelial cells, we found that inflammation induces the degradation of the basement membra...
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Antigen
Molecular biology
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