A novel γ-lactone isolated from the leaves of Pithecellobium dulce (Roxb.) Benth. and its xanthine oxidase activity

A novel 3-(hydroxymethyl)-4-(methylamino)-dihydrofuran-2(3H)-one (1) was isolated for the first time from the leaves of Pithecellobium dulce (Roxb.) Benth., along with kaempferol (2) and kaempferol-3-rhamnoside (3). It demonstrated a promising xanthine oxidase inhibitory activity with IC50 values of 79.0, 0.38, and 70.4 μg/mL (allopurinol = 0.4 µg/mL). This is the first paper to describe the presence of...