Original paper

Deafness mutation in the MYO3A motor domain impairs actin protrusion elongation mechanism

Published: Nov 17, 2021
Abstract
Class III myosins are actin-based motors proposed to transport cargo to the distal tips of stereocilia in the inner ear hairs cells and/or to participate in stereocilia length regulation, which is especially important during development. Mutations in the MYO3A gene are associated with delayed onset deafness. A previous study demonstrated that L697W, a dominant deafness mutation, disrupts MYO3A ATPase and motor properties but does not impair its...
Paper Details
Title
Deafness mutation in the MYO3A motor domain impairs actin protrusion elongation mechanism
Published Date
Nov 17, 2021
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