Genome surveillance by HUSH-mediated silencing of intronless mobile elements
Abstract
All life forms defend their genome against DNA invasion. Eukaryotic cells recognize incoming DNA and limit its transcription through repressive chromatin modifications. The human silencing hub (HUSH) complex transcriptionally represses long interspersed element-1 retrotransposons (L1s) and retroviruses through histone H3 lysine 9 trimethylation (H3K9me3)1-3. How HUSH recognizes and initiates silencing of these invading genetic elements is...
Paper Details
Title
Genome surveillance by HUSH-mediated silencing of intronless mobile elements
Published Date
Nov 18, 2021
Journal
Volume
601
Issue
7893
Pages
440 - 445
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