A sophisticated theory for learning motor skills places emphasis on the need for inferring context — drawing conclusions about the structure of the environment — for efficiently storing and expressing motor memories. null Motor memories rely on inferences about the environment.
DART mission aims to try out a strategy for shielding Earth from killer asteroids. null DART mission aims to try out a strategy for shielding Earth from killer asteroids.
An open letter signed by 145 female scientists from across the world expresses concern over recent dismissals of women leaders. null An open letter signed by 145 female scientists from across the world expresses concern over recent dismissals of women leaders.
Our quest to bring a child into our family led us to confront academic working practices, say Tony Ly and Nathan W. Bailey. null Our quest to bring a child into our family led us to confront academic working practices, say Tony Ly and Nathan W. Bailey.
Last. Paul J. Lehner(University of Cambridge)H-Index: 72
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All life forms defend their genome against DNA invasion. Eukaryotic cells recognize incoming DNA and limit transcription through repressive chromatin modifications. The human silencing hub (HUSH) complex transcriptionally represses long interspersed element-1 retrotransposons (L1s) and retroviruses through histone H3 Lys9 trimethylation (H3K9me3)1–3. How HUSH recognizes and initiates silencing of these invading genetic elements is unknown. Here we show that HUSH is able to recognize and transcri...
#1Lingyun Long(St. Jude Children's Research Hospital)H-Index: 12
#2Jun Wei(St. Jude Children's Research Hospital)H-Index: 16
Last. Hongbo Chi(St. Jude Children's Research Hospital)H-Index: 60
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Nutrients are emerging regulators of adaptive immunity1. Selective nutrients interplay with immunological signals to activate mechanistic target of rapamycin complex 1 (mTORC1), a key driver of cell metabolism2–4, but how these environmental signals are integrated for immune regulation remains unclear. Here we use genome-wide CRISPR screening combined with protein–protein interaction networks to identify regulatory modules that mediate immune receptor- and nutrient-dependent signalling to mTORC1...
Last. Dan H. Barouch(Ragon Institute of MGH, MIT and Harvard)H-Index: 101
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The CVnCoV (CureVac) mRNA vaccine for SARS-CoV-2 has recently been evaluated in a phase 2b/3 efficacy trial in humans1. CV2CoV is a second-generation mRNA vaccine with non-modified nucleosides but optimized non-coding regions and enhanced antigen expression. Here we report a head-to-head study of the immunogenicity and protective efficacy of CVnCoV and CV2CoV in nonhuman primates. We immunized 18 cynomolgus macaques with two doses of 12 ug of lipid nanoparticle formulated CVnCoV, CV2CoV, or sham...
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