Original paper
Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex
Abstract
Not your typical GPCR Among the large family of G protein–coupled receptors (GPCRs) are many orphans, so called because their signaling reactions remain poorly understood. Among these is GPR158 which is highly expressed in the nervous system and implicated in processes from cognition to memory to mood. Patil et al . determined a high-resolution structure of GPR158 alone and bound to a regulator of G protein signaling (RGS) complex. GPR158 has an...
Paper Details
Title
Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex
Published Date
Jan 6, 2022
Journal
Volume
375
Issue
6576
Pages
86 - 91