Original paper
An Ornithine-Free Gramicidin S Analogue Using Norleucine, Cyclo(Val–Nle–Leu–D-Phe–Pro)<sub>2</sub>, Forms Helically Aligned β-Sheets
Volume: 69, Issue: 11, Pages: 1097 - 1103
Published: Oct 31, 2021
Abstract
The structure of an ornithine (Orn)-free Gramicidin S (GS) analogue, cyclo(Val–Nle–Leu–D-Phe–Pro)2 (NGS), was studied. Its circular dichroism (CD) spectrum showed that NGS has a structure similar to GS, though the value of [θ] indicated smaller β-turn and sheet populations. This is probably because the Nle side chain could not form intramolecular hydrogen bonds stabilizing the sheet structure. The chemical shift perturbation of αH and JNH–αH...
Paper Details
Title
An Ornithine-Free Gramicidin S Analogue Using Norleucine, Cyclo(Val–Nle–Leu–D-Phe–Pro)<sub>2</sub>, Forms Helically Aligned β-Sheets
Published Date
Oct 31, 2021
Volume
69
Issue
11
Pages
1097 - 1103