Chemical & Pharmaceutical Bulletin
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#1Keita Komine (Nagasaki University)H-Index: 4
#2Riki Ninomiya (Nagasaki University)
Last. Jun Ishihara (Nagasaki University)H-Index: 24
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SmI2-mediated desymmetrization of a meso-cyclic 1,3-dione pinacol coupling is described. The reaction proceeds with high stereoselectivity to provide fused carbocyclic compounds with three contiguous stereogenic centers featuring an all-carbon quaternary center and a cis-1,2-diol moiety.
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The structure of an ornithine (Orn)-free Gramicidin S (GS) analogue, cyclo(Val-Nle-Leu-D-Phe-Pro)2 (NGS), was studied. Its circular dichroism (CD) spectrum showed that NGS has a structure similar to GS, though the value of [θ] indicated smaller β-turn and sheet populations. This is probably because the Nle side chain could not form intramolecular hydrogen bonds stabilizing the sheet structure. The chemical shift perturbation of αH and JNH-αH were similar in GS and NGS. Three independent NGS mole...
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#1Takato Sakurada (Kyushu University)
#2Ryo Miyahara (Kyushu University)
Last. Yosuke Taniguchi (Kyushu University)H-Index: 17
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γ-Amido-modified 2'-deoxynucleoside triphosphates (dNTPs) and nucleoside triphosphates (NTPs) are becoming increasingly important as biological tools. We herein describe the simple and easy synthesis of γ-amido-dNTPs and -NTPs from commercially available corresponding dNTPs and NTPs in a one-pot reaction using water-soluble carbodiimide and ammonia solution. We examined the effects of synthesized γ-amido-dNTPs on the DNA polymerase reaction. The results obtained showed the incorporation of these...
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#1Shiho Yahata (Kitasato University)
#2Mio Hirose (Kitasato University)
Last. Kumiko Sakai-Kato (Kitasato University)H-Index: 8
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For quantitative analysis, data should be obtained at a sample concentration that is within the range of linearity. We examined the effect of sample concentration on nanoparticle tracking analysis (NTA) of small extracellular vesicles (sEVs), including exosomes, by comparing NTA results of sEVs with those obtained for polystyrene nanoparticles (PSN) and liposomes, which mimic lipid composition and physicochemical properties of exosomes. Initially, NTA of PSN at different concentrations was perfo...
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#1Kenichi Kawano (Kyoto University)H-Index: 8
#2Fumiaki Yokoyama (Kyoto University)H-Index: 3
Last. Shiroh Futaki (Kyoto University)H-Index: 76
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Extracellular vesicles (EVs) have emerged as important targets in biological and medical studies because they are involved in diverse human diseases and bacterial pathogenesis. Although antibodies targeting the surface biomarkers are widely used to detect EVs, peptide-based curvature sensors are currently attracting an attention as a novel tool for marker-free EV detection techniques. We have previously created a curvature-sensing peptide, FAAV and applied it to develop a simple and rapid method...
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#1Yuqin Zhou (ZJUT: Zhejiang University of Technology)H-Index: 1
#2Weitong Hu (KCL: King's College London)
Last. Qingyong Li (ZJUT: Zhejiang University of Technology)H-Index: 5
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In the evaluation of the druggability of candidate compounds, it was vital to predict the oral bioavailability of compounds from apparent permeability (Papp) across Caco-2 cell-culture model of intestinal epithelium cultured on commercial transwell plate inserts. The study was to investigate the transport characteristics and permeability of FL118 (10, 11-Methylenedioxy-20(S)-camptothecin) derivatives 7-Q6 (7-(4-Ethylphenyl)-10, 11-methylenedioxy-20(S)-camptothecin) and 7-Q20 (7-(4-Trifluoromethy...
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#1Hiroki Katayama (Josai University)
Last. Kozo Takayama (Josai University)H-Index: 59
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From the viewpoint of self-medication, it is valuable to develop patient-friendly scored tablets that possess dividing uniformity. In this context, we attempted to optimize the preparation conditions for a tablet with a unique shape, such as a concavely curved scored tablet (CCST). Employing a design of experiment and a response surface method incorporating a thin-plate spline interpolation, and a bootstrap resampling technique, the optimal preparation conditions for CCST were successfully devel...
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#1Tran Thi Minh (Hanoi University of Science and Technology)H-Index: 2
#2Ho Khanh Toan (Hanoi University of Science and Technology)H-Index: 1
Last. Vu Dinh Hoang (Hanoi University of Science and Technology)H-Index: 9
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A phytochemical investigation of methanol extract from leaves of Pachyrhizus erosus (L.) Urban, a leguminous shrub distributed in Vietnam and other tropical and subtropical countries led to the isolation of a new prenylated chalcone, erosusone (1) and a new megastigmane glycoside epimer, 3-episedumoside F1 (9), together with thirteen known compounds including flavonoids (2-6), a 3-benzoxepine lactone (7), a pyridine-4,5-diol derivative (8), megastigmanes and megastigmane glycosides (10-15). Thei...
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#1Kyoko Sugiyama (TMPU: Tohoku Medical and Pharmaceutical University)H-Index: 3
#2Yusuke Sasano (Tohoku University)H-Index: 12
Last. Katsuhiko Sato (TMPU: Tohoku Medical and Pharmaceutical University)H-Index: 4
view all 9 authors...
Nitroxyl radicals, such as 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO), can catalyze the electrochemical oxidation of alcohols and amines. Because the oxidation current obtained in this process depends on the concentration of alcohols and amines, this process can be applied to their sensing. However, the relatively high oxidation potentials required by nitroxyl radicals can induce interfering oxidation currents from various reductive substances in biological samples, which affects the accuracy ...
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Membrane-based rapid test reagents including immunochromatography are widely used in clinical practice. Recently, high-sensitive reagents based on the immunochromatography method, such as silver amplification method and time resolved fluorescence method for influenza testing, has been developed and early confirmation of infection can be achieved. Furthermore, genetic testing, automated all the steps from extraction till detection, is getting popular. Genetic testing of mycoplasma by Smart Gene M...
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