Evolving cancer–niche interactions and therapeutic targets during bone metastasis
Abstract
Many cancer types metastasize to bone. This propensity may be a product of genetic traits of the primary tumour in some cancers. Upon arrival, cancer cells establish interactions with various bone-resident cells during the process of colonization. These interactions, to a large degree, dictate cancer cell fates at multiple steps of the metastatic cascade, from single cells to overt metastases. The bone microenvironment may even influence cancer...
Paper Details
Title
Evolving cancer–niche interactions and therapeutic targets during bone metastasis
Published Date
Oct 5, 2021
Journal
Volume
22
Issue
2
Pages
85 - 101
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Notes
History