Nature Reviews Cancer
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McDowell et al. present mechanistic insights on how obesity-associated neutrophils can modify the lung microenvironment to promote breast cancer cell extravasation.
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Wang et al. showed that monoamine-oxidase A, a regulator of neuronal activity, functions as a negative feedback regulator of T cell activity in tumours.
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#1Daria Briukhovetska (LMU: Ludwig Maximilian University of Munich)H-Index: 1
#2Janina Dörr (LMU: Ludwig Maximilian University of Munich)
Last. Sebastian Kobold (LMU: Ludwig Maximilian University of Munich)H-Index: 24
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Interleukins and associated cytokines serve as the means of communication for innate and adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a critical role in cancer development, progression and control. Interleukins can nurture an environment enabling and favouring cancer growth while simultaneously being essential for a productive tumour-directed immune response. These properties of interleukins can be exploited to improve immunotherapies to promote effectiv...
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Griffin, Wu, Iracheta-Vellve et al. identified SETDB1 as an immunosuppressive epigenetic modulator in cancer.
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#1Piotr K. Kopinski (Children's Hospital of Philadelphia)H-Index: 5
#2Larry N. Singh (Children's Hospital of Philadelphia)H-Index: 18
Last. Douglas C. Wallace (UPenn: University of Pennsylvania)H-Index: 147
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Variation in the mitochondrial DNA (mtDNA) sequence is common in certain tumours. Two classes of cancer mtDNA variants can be identified: de novo mutations that act as ‘inducers’ of carcinogenesis and functional variants that act as ‘adaptors’, permitting cancer cells to thrive in different environments. These mtDNA variants have three origins: inherited variants, which run in families, somatic mutations arising within each cell or individual, and variants that are also associated with ancient m...
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#1Ebony O. McGee (Vandy: Vanderbilt University)H-Index: 15
Black people have the highest cancer rates in the USA owing to systemic racism — biased systems that put pressure on Black lives every day. STEM scholars have a responsibility to reduce the historical trauma associated with systemic racism. This also means challenging systemic racism within STEM fields.
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Zhang et al. show that, in mouse models, bone metastases can seed metastases in other organs and that this is driven by EZH2-mediated epigenetic reprogramming to promote stem cell-like features.
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#1Shuai Zhao (UNC: University of North Carolina at Chapel Hill)H-Index: 1
#2C. David Allis (Rockefeller University)H-Index: 134
Last. Gang Greg Wang (UNC: University of North Carolina at Chapel Hill)H-Index: 27
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The genetic information of human cells is stored in the context of chromatin, which is subjected to DNA methylation and various histone modifications. Such a ‘language’ of chromatin modification constitutes a fundamental means of gene and (epi)genome regulation, underlying a myriad of cellular and developmental processes. In recent years, mounting evidence has demonstrated that miswriting, misreading or mis-erasing of the modification language embedded in chromatin represents a common, sometimes...
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#2Ha X. Dang (WashU: Washington University in St. Louis)H-Index: 16
Last. Christopher G. MaherH-Index: 145
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Metastasis is a major contributor to cancer-associated deaths. It is characterized by a multistep process that occurs through the acquisition of molecular and phenotypic changes enabling cancer cells from a primary tumour to disseminate and colonize at distant organ sites. Over the past decade, the discovery and characterization of long noncoding RNAs (lncRNAs) have revealed the diversity of their regulatory roles, including key contributions throughout the metastatic cascade. Here, we review ho...
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#1Andrew E. Whiteley (Duke University)
#2Trevor T. Price (Duke University)H-Index: 6
Last. Dorothy A. Sipkins (Duke University)H-Index: 14
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In contrast to solid cancers, which often require genetic modifications and complex cellular reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the innate ability for migration and invasion. Dedifferentiated, malignant leukocytes retain the benign leukocytes’ capacity for cell motility and survival in the circulation, while acquiring the potential for rapid and uncontrolled cell division. For these reasons, leukaemias, although not traditionally considered as ...
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