Nature Reviews Cancer
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#1Robert L. Copeland (HU: Howard University)H-Index: 12
#2Yasmine Kanaan (HU: Howard University)H-Index: 12
In this Journal Club, Robert L. Copeland and Yasmine Kanaan discuss a paper that reports how ERβ and IGF2 signalling may contribute to the heterogeneity of triple-negative breast cancer observed in patients with different ancestries in the USA.
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#1Robert L. Satcher (University of Texas MD Anderson Cancer Center)H-Index: 21
#2Xiang Zhang (BCM: Baylor College of Medicine)H-Index: 163
Many cancer types metastasize to bone. This propensity may be a product of genetic traits of the primary tumour in some cancers. Upon arrival, cancer cells establish interactions with various bone-resident cells during the process of colonization. These interactions, to a large degree, dictate cancer cell fates at multiple steps of the metastatic cascade, from single cells to overt metastases. The bone microenvironment may even influence cancer cells to subsequently spread to multiple other orga...
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Berta et al. show that epigenetic remodelling promotes the development of uterine fibroids.
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#1Brian M Andersen (Harvard University)
#2Camilo Faust Akl (Brigham and Women's Hospital)
Last. Francisco J. Quintana (Broad Institute)H-Index: 72
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Brain cancers carry bleak prognoses, with therapeutic advances helping only a minority of patients over the past decade. The brain tumour microenvironment (TME) is highly immunosuppressive and differs from that of other malignancies as a result of the glial, neural and immune cell populations that constitute it. Until recently, the study of the brain TME was limited by the lack of methods to de-convolute this complex system at the single-cell level. However, novel technical approaches have begun...
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#1Sarah Killcoyne (University of Cambridge)H-Index: 13
#2Rebecca C. Fitzgerald (University of Cambridge)H-Index: 71
Cancer cells are shaped through an evolutionary process of DNA mutation, cell selection and population expansion. Early steps in this process are driven by a set of mutated driver genes and structural alterations to the genome through copy number gains or losses. Oesophageal adenocarcinoma (EAC) and the pre-invasive tissue, Barrett's oesophagus (BE), provide an ideal example in which to observe and study this evolution. BE displays early genomic instability, specifically in copy number changes t...
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#1Olivier Elemento (Cornell University)H-Index: 82
#2Christina S. Leslie (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 62
Last. Georgia D. Tourassi (National Center for Computational Sciences)H-Index: 30
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Artificial intelligence and machine learning techniques are breaking into biomedical research and health care, which importantly includes cancer research and oncology, where the potential applications are vast. These include detection and diagnosis of cancer, subtype classification, optimization of cancer treatment and identification of new therapeutic targets in drug discovery. While big data used to train machine learning models may already exist, leveraging this opportunity to realize the ful...
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Using zebrafish and human pluripotent stem cell-derived models of melanoma, Baggiolini, Callahan et al. demonstrate that cells expressing progenitor-like programmes and specific chromatin-modifying enzymes are more readily transformed by BRAFV600E.
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#1Brian M. Rivers (Morehouse School of Medicine)H-Index: 11
In this Journal Club, Brian Rivers highlights a study aimed at enhancing the participation of African American patients in cancer clinical trials.
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Oren et al. developed a lentiviral barcode library, called Watermelon, to characterize the rare population of cycling persister cancer cells that arise during the course of drug treatment and promote tumour relapse.
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#1Anabel Eckerling (TAU: Tel Aviv University)H-Index: 1
#2Itay Ricon-Becker (TAU: Tel Aviv University)H-Index: 2
Last. Shamgar Ben-Eliyahu (TAU: Tel Aviv University)H-Index: 53
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The notion that stress and cancer are interlinked has dominated lay discourse for decades. More recent animal studies indicate that stress can substantially facilitate cancer progression through modulating most hallmarks of cancer, and molecular and systemic mechanisms mediating these effects have been elucidated. However, available clinical evidence for such deleterious effects is inconsistent, as epidemiological and stress-reducing clinical interventions have yielded mixed effects on cancer mo...
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