The Enzymatic Activity of Inosine 5′-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for Staphylococcus aureus Infections
Abstract
Many bacterial pathogens, including Staphylococcus aureus, require inosine 5'-monophosphate dehydrogenase (IMPDH) for infection, making this enzyme a promising new target for antibiotics. Although potent selective inhibitors of bacterial IMPDHs have been reported, relatively few have displayed antibacterial activity. Here we use structure-informed design to obtain inhibitors of S. aureus IMPDH (SaIMPDH) that have potent antibacterial activity...
Paper Details
Title
The Enzymatic Activity of Inosine 5′-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for Staphylococcus aureus Infections
Published Date
Sep 30, 2021
Journal
Volume
7
Issue
11
Pages
3062 - 3076
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