ACS Infectious Diseases
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#1Surabhi Surabhi (University of Greifswald)H-Index: 1
#2Lana H Jachmann (University of Greifswald)
Last. Nikolai Siemens (University of Greifswald)H-Index: 9
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Community-acquired pneumonia is an infection of the lower respiratory tract caused by various viral and bacterial pathogens, including influenza A virus (IAV), Streptococcus pneumoniae, and Staphylococcus aureus. To understand the disease pathology, it is important to delineate host metabolic responses to an infection. In this study, metabolome profiling of mono- and coinfected human bronchial epithelial cells was performed. We show that IAV and S. aureus silently survive within the cells with a...
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#2Diana Priscila Penso Pires (University of Minho)H-Index: 10
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Klebsiella pneumoniae is a Gram-negative bacterium that has become one of the leading causes of life-threatening healthcare-associated infections (HAIs), including pneumonia and sepsis. Moreover, due to its increasingly antibiotic resistance, K. pneumoniae has been declared a global top priority concern. The problem of K. pneumoniae infections is due, in part, to the inability to detect this pathogen rapidly and accurately and thus to treat patients within the early stages of infections. The suc...
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#1Elyse M. Digby (U of T: University of Toronto)H-Index: 2
#2Ma T (U of T: University of Toronto)
Last. Andrew A. Beharry (U of T: University of Toronto)H-Index: 12
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Antimicrobial photodynamic therapy (APDT) employs a photosensitizer, light, and molecular oxygen to treat infectious diseases via oxidative damage, with a low likelihood for the development of resistance. For optimal APDT efficacy, photosensitizers with cationic charges that can permeate bacteria cells and bind intracellular targets are desired to not limit oxidative damage to the outer bacterial structure. Here we report the application of brominated DAPI (Br-DAPI), a water-soluble, DNA-binding...
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#1Dmitri SvetlovH-Index: 5
#2Irina Artsimovitch (OSU: Ohio State University)H-Index: 45
The tragic consequences of the COVID-19 pandemic have led to admirable responses by the global scientific community, including a profound acceleration in the pace of research and exchange of findings. However, this has had considerable costs of its own, as erroneous conclusions have propagated faster than researchers have been able to detect and correct them. We illustrate the specific misunderstandings that have resulted from reductionist approaches to the study of SARS-CoV-2 RNA-dependent RNA ...
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#1Cynthia Tallant (GSK: GlaxoSmithKline)
#2Paul Bamborough (GSK: GlaxoSmithKline)H-Index: 30
Last. Daniel F. Simola (GSK: GlaxoSmithKline)H-Index: 12
view all 12 authors...
This Perspective discusses the published data and recent developments in the research area of bromodomains in parasitic protozoa. Further work is needed to evaluate the tractability of this target class in the context of infectious diseases and launch drug discovery campaigns to identify and develop antiparasite drugs that can offer differentiated mechanisms of action.
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#1Mohammad Aqdas (CSIR: Council of Scientific and Industrial Research)H-Index: 9
#2Sudeep K. Maurya (CSIR: Council of Scientific and Industrial Research)H-Index: 6
Last. Javed N. Agrewala (IIT-RPR: Indian Institute of Technology Ropar)H-Index: 29
view all 8 authors...
Tuberculosis (TB) treatment is lengthy and inflicted with severe side-effects. Here, we attempted a novel strategy to reinforce host immunity through NOD-like receptor (NOD-2) and Toll-like receptor (TLR-4) signaling in the murine model of TB. Intriguingly, we noticed that it not only bolstered the immunity but also reduced the dose and duration of rifampicin and isoniazid therapy. Further, we observed expansion in the pool of effector (CD44hi, CD62Llo, CD127hi) and central (CD44hi, CD62Lhi, CD1...
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#1Lindsey N. Miller (UT: University of Tennessee)H-Index: 1
#2Marea J. Blake (UT: University of Tennessee)H-Index: 1
Last. Tessa R. Calhoun (UT: University of Tennessee)H-Index: 15
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Advancements in antibiotic drug design are often hindered by missing information on how these small molecules interact with living cells. The antibiotic, daptomycin, has found clinical success and an emerging resistance, but a comprehensive picture of its mechanism of action has remained elusive. Using a surface-specific spectroscopy technique, second harmonic generation, we are able to quantitatively assess the binding of daptomycin to living cell membranes without the addition of exogenous lab...
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#1Bruce Lin (University of Melbourne)
#2Rong Li (Florey Institute of Neuroscience and Mental Health)
Last. Neil M O'Brien-Simpson (University of Melbourne)H-Index: 41
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Oral dental infections are one of the most common diseases affecting humans, with caries and periodontal disease having the highest incidence. Caries and periodontal disease arise from infections caused by oral bacterial pathogens. Current misuse and overuse of antibiotic treatments have led to the development of antimicrobial resistance. However, recent studies have shown that cationic antimicrobial peptides are a promising family of antibacterial agents that are active against oral pathogenic ...
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#1Gyan Modi (Brandeis University)H-Index: 10
#2Gary M Marqus (Brandeis University)
Last. Ryan T Cullinane (Brandeis University)
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Many bacterial pathogens, including Staphylococcus aureus, require inosine 5'-monophosphate dehydrogenase (IMPDH) for infection, making this enzyme a promising new target for antibiotics. Although potent selective inhibitors of bacterial IMPDHs have been reported, relatively few have displayed antibacterial activity. Here we use structure-informed design to obtain inhibitors of S. aureus IMPDH (SaIMPDH) that have potent antibacterial activity (minimal inhibitory concentrations less than 2 μM) an...
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Chemistry
Antibiotics
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