Original paper
The Role of Mesostriatal Dopamine System and Corticostriatal Glutamatergic Transmission in Chronic Pain
Abstract
There is increasing recognition of the involvement of the nigrostriatal and mesolimbic dopamine systems in the modulation of chronic pain. The first part of the present article reviews the evidence indicating that dopamine exerts analgesic effects during persistent pain by stimulating the D2 receptors in the dorsal striatum and nucleus accumbens (NAc). Thereby, dopamine inhibits striatal output via the D2 receptor-expressing medium spiny neurons...
Paper Details
Title
The Role of Mesostriatal Dopamine System and Corticostriatal Glutamatergic Transmission in Chronic Pain
Published Date
Oct 2, 2021
Journal
Volume
11
Issue
10
Pages
1311 - 1311