TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer
Abstract
Sex disparity in cancer is so far inadequately considered, and components of its basis are rather unknown. We reveal that male versus female pancreatic cancer (PC) patients and mice show shortened survival, more frequent liver metastasis, and elevated hepatic metastasis-promoting gene expression. Tissue inhibitor of metalloproteinases 1 (TIMP1) was the secreted factor with the strongest male-biased expression in patient-derived pancreatic...
Paper Details
Title
TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer
Published Date
Sep 17, 2021
Volume
218
Issue
11
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