Neuroinflammation May Indeed Be a Major Player in Opioid Use Disorder in Humans.

Published on Oct 15, 2021in Biological Psychiatry13.382
· DOI :10.1016/J.BIOPSYCH.2021.08.005
Ilia N. Karatsoreos38
Estimated H-index: 38
(UMass: University of Massachusetts Amherst)
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Abstract
References9
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#1Austin Ferro (CSHL: Cold Spring Harbor Laboratory)H-Index: 1
#2Yohan S. S. Auguste (CSHL: Cold Spring Harbor Laboratory)H-Index: 1
Last. Lucas Cheadle (CSHL: Cold Spring Harbor Laboratory)H-Index: 1
view all 3 authors...
Intercellular signaling molecules such as cytokines and their receptors enable immune cells to communicate with one another and their surrounding microenvironments. Emerging evidence suggests that the same signaling pathways that regulate inflammatory responses to injury and disease outside of the brain also play powerful roles in brain development, plasticity, and function. These observations raise the question of how the same signaling molecules can play such distinct roles in peripheral tissu...
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#1Marianne L. Seney (University of Pittsburgh)H-Index: 21
#2Sam-Moon Kim (University of Pittsburgh)H-Index: 3
Last. Chaitanya Srinivasan (CMU: Carnegie Mellon University)H-Index: 2
view all 15 authors...
Abstract null null Background null Prevalence rates of opioid use disorder (OUD) have increased dramatically, accompanied by a surge of overdose deaths. While opioid dependence has been extensively studied in preclinical models, an understanding of the biological alterations that occur in the brains of people who chronically use opioids and who are diagnosed with OUD remains limited. To address this limitation, RNA-sequencing (RNA-seq) was conducted on the dorsolateral prefrontal cortex (DLPFC) ...
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#4Matthew Hickman (UoB: University of Bristol)H-Index: 46
Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that drive adverse emotional states and relapse. However, successful recovery is possible with appropriate treatment, although with a persisting propensity to relapse. The individual and public health burdens of OUD are immense; 26.8 million people were estimated to be living with OUD globally in 2016, with >100,000 op...
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#1Marco Prinz (University of Freiburg)H-Index: 102
#2Steffen Jung (Weizmann Institute of Science)H-Index: 108
Last. Josef Priller (Charité)H-Index: 72
view all 3 authors...
Microglia were first recognized as a distinct cell population in the CNS one century ago. For a long time, they were primarily considered to be phagocytes responsible for removing debris during CNS development and disease. More recently, advances in imaging and genetics and the advent of single-cell technologies provided new insights into the much more complex and fascinating biology of microglia. The ontogeny of microglia was identified, and their functions in health and disease were better def...
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#1Yan Dong (University of Pittsburgh)H-Index: 35
#2Jane R. Taylor (Yale University)H-Index: 76
Last. Yavin Shaham (NIDA: National Institute on Drug Abuse)H-Index: 99
view all 4 authors...
High rates of relapse to drug use during abstinence is a defining feature of human drug addiction. This clinical scenario has been studied at the preclinical level using different animal models in which relapse to drug seeking is assessed after cessation of operant drug self-administration in rodents and monkeys. In our Society for Neuroscience (SFN) session entitled “Circuit and Synaptic Plasticity Mechanisms of Drug Relapse,” we will discuss new developments of our understanding of circuits an...
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#1Theo Vos (UW: University of Washington)H-Index: 163
Last. Semaw Ferede Abera (Mekelle University)H-Index: 43
view all 727 authors...
Summary Background As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. Methods We estimated prevalence and incidence fo...
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#1Nora D. Volkow (NIDA: National Institute on Drug Abuse)H-Index: 185
#2Marisela Morales (NIDA: National Institute on Drug Abuse)H-Index: 60
Advances in neuroscience identified addiction as a chronic brain disease with strong genetic, neurodevelopmental, and sociocultural components. We here discuss the circuit- and cell-level mechanisms of this condition and its co-option of pathways regulating reward, self-control, and affect. Drugs of abuse exert their initial reinforcing effects by triggering supraphysiologic surges of dopamine in the nucleus accumbens that activate the direct striatal pathway via D1 receptors and inhibit the ind...
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Immune responses in the CNS are common, despite its perception as a site of immune privilege. These responses can be mediated by resident microglia and astrocytes, which are innate immune cells without direct counterparts in the periphery. Furthermore, CNS immune reactions often take place in virtual isolation from the innate/adaptive immune interplay that characterizes peripheral immunity. However, microglia and astrocytes also engage in significant cross-talk with CNS-infiltrating T cells and ...
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#1Julie A. Kauer (Brown University)H-Index: 44
#2Robert C. Malenka (Stanford University)H-Index: 161
Drugs of abuse alter synaptic plasticity mechanisms in key brain circuits. Kauer and Malenka review the drug-induced synaptic modifications that take place in the mesolimbic dopamine system, which is central to reward processing and contributes to addiction.
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