Biological Psychiatry
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#1Lei Guo (MSSM: Icahn School of Medicine at Mount Sinai)H-Index: 6
#2Margaret B. Zhong (CU: Columbia University)H-Index: 3
Last. Dongming CaiH-Index: 18
view all 5 authors...
Alzheimer's disease (AD) has complex etiologies, and the impact of sex on AD varies over the course of disease development. The literature provides some evidence of sex-specific contributions to AD. However, molecular mechanisms of sex-biased differences in AD remain elusive. Multiomics data in tandem with systems biology approaches offer a new avenue to dissect sex-stratified molecular mechanisms of AD and to develop sex-specific diagnostic and therapeutic strategies for AD. Single-cell transcr...
#1Ryan W. Logan (BU: Boston University)H-Index: 5
#2Xiangning Xue (University of Pittsburgh)H-Index: 3
Last. Marianne L. Seney (University of Pittsburgh)H-Index: 21
view all 8 authors...
Abstract null null Background null Diurnal rhythms in gene expression have been detected in the human brain. Previous studies found that males and females exhibit 24-hour rhythms in known circadian genes, with earlier peak expression in females. Whether there are sex differences in large-scale transcriptional rhythms in the cortex that align with observed sex differences in physiological and behavioral rhythms is currently unknown. null null null Methods null Diurnal rhythmicity of gene expressi...
#1Robert Hitzemann (OHSU: Oregon Health & Science University)H-Index: 39
#2Susan E. Bergeson (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 10
Last. Tamara J. Phillips (OHSU: Oregon Health & Science University)H-Index: 41
view all 22 authors...
There is compelling evidence that sex and gender have crucial roles in excessive alcohol (ethanol) consumption. Here, we review some of the data from the perspective of brain transcriptional differences between males and females, focusing on rodent animal models. A key emerging transcriptional feature is the role of neuroimmune processes. Microglia are the resident neuroimmune cells in the brain and exhibit substantial functional differences between males and females. Selective breeding for bing...
Both history of early-life stress (ELS) and female sex are associated with increased risk for depression. The complexity of how ELS interacts with brain development and sex to impart risk for multifaceted neuropsychiatric disorders is also unlikely to be understood by examining changes in single genes. Here, we review an emerging literature on genome-wide transcriptional and epigenetic signatures of ELS and the potential moderating influence of sex. We discuss evidence both that there are latent...
#1Eran A. Mukamel (UCSD: University of California, San Diego)H-Index: 25
#2Jakob GroveH-Index: 38
Last. Jill M. GoldsteinH-Index: 63
view all 131 authors...
Background null Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. null Methods null We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MD...
#1Marianne L. Seney (University of Pittsburgh)H-Index: 21
#2Jill R. Glausier (University of Pittsburgh)H-Index: 14
Last. Etienne Sibille (University of Toronto)H-Index: 47
view all 3 authors...
Major depressive disorder (MDD) is a leading cause of disability, affecting more than 300 million people worldwide. We first review the well-known sex difference in incidence of MDD, with women being twice as likely to be diagnosed as men, and briefly summarize how the impact of MDD varies between men and women, with sex differences in symptoms, severity, and antidepressant drug response. We then attempt to deconstruct the biological bases for MDD and discuss implications for sex differences res...
#1Deena M. Walker (MSSM: Icahn School of Medicine at Mount Sinai)H-Index: 27
#2Ashley M. Cunningham (MSSM: Icahn School of Medicine at Mount Sinai)H-Index: 8
Last. Eric J. Nestler (MSSM: Icahn School of Medicine at Mount Sinai)H-Index: 162
view all 3 authors...
#1Marianne L. Seney (University of Pittsburgh)H-Index: 21
#2Eric J. Nestler (MSSM: Icahn School of Medicine at Mount Sinai)H-Index: 162
#1Diana Tavares-Ferreira (UTD: The University of Texas at Dallas)H-Index: 6
#2Pradipta R. Ray (UTD: The University of Texas at Dallas)H-Index: 16
Last. Theodore J. Price (UTD: The University of Texas at Dallas)H-Index: 46
view all 12 authors...
Abstract null null Background null There are clinically relevant sex differences in acute and chronic pain mechanisms, but we are only beginning to understand their mechanistic basis. Transcriptome analyses of rodent whole dorsal root ganglion (DRG) have revealed sex differences, mostly in immune cells. We examined the transcriptome and translatome of the mouse DRG with the goal of identifying sex differences. null null null Methods null We used translating ribosome affinity purification sequenc...
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