Carbetocin Compared With Oxytocin in Nonelective Cesarean Delivery: A Systematic Review, Meta-analysis, and Trial Sequential Analysis of Randomized-controlled Trials

( Can J Anesth . 2020;67:1524–1534) Uterotonic agents, such as oxytocin and carbetocin, are used in the management of uterine atony, a major cause of postpartum hemorrhage (PPH). While oxytocin and carbetocin both have fast onset of action, oxytocin has a short duration of action, requiring immediate intravenous (IV) infusion during the perioperative period. In contrast, carbetocin has a longer duration with effects lasting for 60 minutes after...