Original paper

Valproate activates the Snf1 kinase in Saccharomyces cerevisiae by decreasing the cytosolic pH

Volume: 297, Issue: 4, Pages: 101110 - 101110
Published: Oct 1, 2021
Abstract
Valproate (VPA) is a widely used mood stabilizer, but its therapeutic mechanism of action is not understood. This knowledge gap hinders the development of more effective drugs with fewer side effects. Using the yeast model to elucidate the effects of VPA on cellular metabolism, we determined that the drug upregulated expression of genes normally repressed during logarithmic growth on glucose medium and increased levels of activated...
Paper Details
Title
Valproate activates the Snf1 kinase in Saccharomyces cerevisiae by decreasing the cytosolic pH
Published Date
Oct 1, 2021
Volume
297
Issue
4
Pages
101110 - 101110
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