Production and Evaluation of In-vitro and In-vivo Effects of P28-IL24, a Promising Anti-breast Cancer Fusion Protein

Interleukin-24 (IL-24) is known to selectively induce apoptosis in cancer cells through endoplasmic reticulum (ER) stress. However, this protein alone is unable to enter cells and consequently it is not able to inhibit cell proliferation. In this study, we developed a novel recombinant chimeric protein containing IL-24 which is linked to P28, a cancer specific cell-penetrating peptide and P53 stabilizer, to target IL-24 into breast cancer cells....