Reza Ghavimi
Isfahan University of Medical Sciences
FermentationGeneGenome-wide association studyCytotoxicityLivestockFusion proteinRestriction enzymeGenotypeSNPFunction (biology)Case-control studyAntigenHippocampal formationSingle-nucleotide polymorphismCytotoxic T cellRestriction fragment length polymorphismBioreactorHomology modelinglac operonConotoxinBacterial growthChemistryPrevalenceVoltage-dependent calcium channelMedical microbiologyApoptosisParasitologyHaplotypeIn vitroImmunologyInclusion bodiesCombinatorial chemistryInducerIn silicoEchinococcus granulosusZiconotideCD226Animal modelMyelinDiseasePeptideInterleukin-36HLA-GMetacestodeLinkerMultiple sclerosisMTT assayAnalgesicCD86CD58PopulationDemyelinating DisorderBiological evaluationIn patientCox1 geneMorphine withdrawalGenotypingHigh Resolution MeltEcology (disciplines)Veterinary medicineReal-time polymerase chain reactionCancer researchCentral nervous systemGeneticsYield (chemistry)Escherichia coliFlow cytometryBiochemistryNMDA receptorComputational biologyMedicineBiologyImmune systemCancer cellPharmacology
10Publications
5H-index
29Citations
Publications 11
Newest
#1Reza Ghavimi (IUMS: Isfahan University of Medical Sciences)H-Index: 5
#2Vajihe Akbari (IUMS: Isfahan University of Medical Sciences)H-Index: 12
Last. Ali Jahanian-Najafabadi (IUMS: Isfahan University of Medical Sciences)H-Index: 15
view all 3 authors...
Interleukin-24 (IL-24) is known to selectively induce apoptosis in cancer cells through endoplasmic reticulum (ER) stress. However, this protein alone is unable to enter cells and consequently it is not able to inhibit cell proliferation. In this study, we developed a novel recombinant chimeric protein containing IL-24 which is linked to P28, a cancer specific cell-penetrating peptide and P53 stabilizer, to target IL-24 into breast cancer cells. After design, expression and purification of the P...
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#1Ali Ghasemi (Semnan University)
#2Reza Ghavimi (IUMS: Isfahan University of Medical Sciences)H-Index: 5
Last. Mohsen Mohammadi (Bushehr University of Medical Sciences)H-Index: 8
view all 5 authors...
Breast cancer is one of the well-known non-cutaneous cancers among women worldwide. In the present study, we have characterized the anti-cancer activity of Moronecidin-like peptide derived from the Hippocampus comes in comparison with a well-known antimicrobial peptide (AMP), Piscidin. Evaluation of the cytotoxic activity of the peptides against 4T1 cancer cells and bone marrow-derived dendritic cells (BMDCs) using MTT assay and flow cytometry demonstrated a concentration-dependent cytotoxicity ...
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#1Hooman Bozorgi (Semnan University)H-Index: 3
#2Ehsan Motaghi (Kurdistan University of Medical Sciences)H-Index: 4
Last. Reza Ghavimi (IUMS: Isfahan University of Medical Sciences)H-Index: 5
view all 4 authors...
ɷ-Conotoxin MVIIA (ziconotide or SNX-111) is an atypical analgesic drug with the water-soluble formulation and routinely is injected into the brain and spinal regions in human and animal model stud...
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#1Reza Ghavimi (IUMS: Isfahan University of Medical Sciences)H-Index: 5
#2Fereshteh Alsahebfosoul (UI: University of Isfahan)H-Index: 7
Last. Ahmad Zavaran HosseiniH-Index: 12
view all 6 authors...
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#1Reza Ghavimi (IUMS: Isfahan University of Medical Sciences)H-Index: 5
#2Elmira Mohammadi (IUMS: Isfahan University of Medical Sciences)H-Index: 4
Last. Ali Jahanian-Najafabadi (IUMS: Isfahan University of Medical Sciences)H-Index: 15
view all 5 authors...
Background and purpose: An anticancer peptide P28, has shown to be cytolethal on various cancer cells including breast cancer. Moreover, p28 can be also used as a targeting moiety in the structure of fusion proteins. IL-24 (or its truncated form, M4) is a cytokine with anticancer activity against a wide range of tumor cells. We aimed at production of a fusion protein consisted of p28 and either IL-24 or M4 to target breast cancer. However, selection of a proper linker to join the two moieties wi...
Source
#1Sahand Safari (Ardabil University of Medical Sciences)H-Index: 1
#2Reza Ghavimi (IUMS: Isfahan University of Medical Sciences)H-Index: 5
Last. Saghi Sepehri (Ardabil University of Medical Sciences)H-Index: 10
view all 4 authors...
Source
#1Mohammad Ali Mohaghegh (IUMS: Isfahan University of Medical Sciences)H-Index: 8
#2Hossein Yousofi-Darani (IUMS: Isfahan University of Medical Sciences)H-Index: 1
Last. Seyed Hossein Hejazi (IUMS: Isfahan University of Medical Sciences)H-Index: 15
view all 10 authors...
Source
#1Mohammad Ali Mohaghegh (IUMS: Isfahan University of Medical Sciences)H-Index: 8
#2Hossein Yousofi-Darani (IUMS: Isfahan University of Medical Sciences)H-Index: 1
Last. Seyed Hossein Hejazi (IUMS: Isfahan University of Medical Sciences)H-Index: 15
view all 10 authors...
Purpose Cystic echinococcosis (CE), caused by the metacestode of Echinococcus granulosus, is highly endemic over large parts of Iran. The purpose of this study was to investigate the prevalence rate of hydatidosis and mitochondrial cox1 real-time PCR with high-resolution melting curve (HRM) analysis of E. granulosus isolated from human and livestock.
Source
#1Raziyeh Malekian (IUMS: Isfahan University of Medical Sciences)H-Index: 2
#2Ali Jahanian-Najafabadi (IUMS: Isfahan University of Medical Sciences)H-Index: 15
Last. Vajihe Akbari (IUMS: Isfahan University of Medical Sciences)H-Index: 12
view all 6 authors...
A novel strategy to increase protein expression yield is unintended induction of expression in complex media, called auto-induction. This method can be used to express proteins under control of the lac promoter without any need to monitor bacterial growth pattern, and addition of specific expression inducers such as Isopropyl β-D-1-thiogalactopyranoside (IPTG) at proper time. In the present study, a codon optimized gene encoding granulocyte-macrophage colony stimulating factor (GM-CSF) was clone...
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#1Fereshteh Alsahebfosoul (IUMS: Isfahan University of Medical Sciences)H-Index: 7
#2Hamidreza Jahanbani-Ardakani (IUMS: Isfahan University of Medical Sciences)H-Index: 5
Last. Masoud Etemadifar (IUMS: Isfahan University of Medical Sciences)H-Index: 28
view all 5 authors...
Introduction: Multiple sclerosis is a chronic autoimmune demyelinating disorder of central nervous system with unknown origin. In MS disease, T cells are pointed to myelin antigens and it leads to ...
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