Emerging role of signal transducer and activator of transcription 3 (STAT3) in pituitary adenomas.

Published on Jul 10, 2021in Endocrine Journal2.349
· DOI :10.1507/ENDOCRJ.EJ21-0106
Cyndy Liu (U of A: University of Alberta), Tae Nakano-Tateno4
Estimated H-index: 4
(U of A: University of Alberta)
+ 2 AuthorsToru Tateno15
Estimated H-index: 15
(U of A: University of Alberta)
Pituitary adenomas are benign tumours that can cause an individual various clinical manifestations including tumour mass effects and/or the diverse effects of abnormal pituitary hormone secretion. Given the morbidity and limited treatment options for pituitary adenomas, there is a need for better biomarkers and treatment options. One molecule that is of specific interest is the signal transducer and activator of transcription 3 (STAT3), a transcription factor that plays a critical role in mediating cytokine-induced changes in gene expression. In addition, STAT3 controls cell proliferation by regulating mitochondrial activity. Not only does activation of STAT3 play a crucial role in tumorigenesis, including pituitary tumorigenesis, but a number of studies also demonstrate pharmacological STAT3 inhibition as a promising treatment approach for many types of tumours, including pituitary tumours. This review will focus on the role of STAT3 in different pituitary adenomas, in particular, growth hormone-producing adenomas and null cell adenomas. Furthermore, how STAT3 is involved in the cell proliferation and hormone regulation in pituitary adenomas and its potential role as a molecular therapeutic target in pituitary adenomas will be summarized.
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