Endocrine Journal
Papers 3916
1 page of 392 pages (3,916 results)
#1Atsuhito Suyama (Okayama University)H-Index: 1
#2Nahoko Iwata (Okayama University)H-Index: 5
Last. Fumio Otsuka (Okayama University)H-Index: 35
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The functional role of the transcription factors NR5A1 and NR5A2 and their interaction with Clock gene and bone morphogenetic proteins (BMPs) were investigated in human granulosa KGN cells. Treatment with BMP-15 and GDF-9 suppressed forskolin (FSK)-induced steroidogenesis as shown by the mRNA expression levels of StAR and P450scc but not the mRNA expression level of P450arom. Of interest, treatment with BMP-15 and GDF-9 also suppressed FSK-induced NR5A2 mRNA expression. Treatment with BMP-15 sup...
#1Akihiro Ohmoto (JFCR: Japanese Foundation for Cancer Research)H-Index: 7
#2Yasuyuki Shigematsu (JFCR: Japanese Foundation for Cancer Research)H-Index: 4
Last. Makiko Ono (JFCR: Japanese Foundation for Cancer Research)H-Index: 14
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Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis. While mitotane is the only agent approved for ACC, clinical data are scarce, especially in the Asian population. We reviewed 10 patients with ACC who received mitotane as a single agent or in combination with other agents in our institution. Patient characteristics, clinical outcomes, and toxicities were analyzed. Mitotane was administered to 2 patients as an adjuvant therapy and to 8 patients for systemic control. In the...
#1Naoki Edo (Teikyo University)H-Index: 4
#2Koji Morita (Teikyo University)H-Index: 4
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Serum dehydroepiandrosterone sulfate (DHEA-S) levels reflect the state of adrenocorticotropic hormone (ACTH) secretion. However, it is difficult to use serum DHEA-S to diagnose hypothalamic-pituitary-adrenal (HPA) axis insufficiency due to its non-normal and highly skewed distribution. In this study, we focused on HPA insufficiency caused by hypothalamic and/or pituitary dysfunction and evaluated the usefulness of the standard deviation score of log-transformed DHEA-S (ln DHEA-S SD score), which...
#1Makoto FujishimaH-Index: 1
#2Akira MiyauchiH-Index: 80
Last. Hiroo MasuokaH-Index: 15
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Identification of the parathyroid glands during surgery is crucial for preventing postoperative hypoparathyroidism. Kikumori et al. reported that the aspartate aminotransferase (AST)/lactate dehydrogenase (LDH) ratio for the saline suspension of a suspicious tissue can differentiate parathyroid tissue from other tissues. The aim of this study was to evaluate the utility of this method and investigate the appropriate time for measurement. We obtained 465 tissue specimens during thyroidectomy of 1...
Gamma-glutamylcyclotransferase (GGCT) can promote the progression of osteosarcoma (OS). MicroRNAs also play significant roles in regulating the progression of OS. This study was designed to investigate whether miR-877 exerts its function in OS by targeting GGCT. The proliferation of OS cells (Saos-2 and U2OS) was detected by MTT and colony formation assays. The migration and invasion of OS cells were detected by transwell assays. The expressions of miRNAs and GGCT were detected by quantitative r...
#1Toshitetsu HayashiH-Index: 8
#2Noriko AkiyamaH-Index: 5
Last. Akira MiyauchiH-Index: 80
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Rapid on-site evaluation of fine-needle aspiration cytology is time-consuming and requires specialized cytopathology staff. Mobile Rose® is a newly developed device for rapid on-site evaluation of fine-needle aspiration cytology. This study aimed to investigate the potential role of Mobile Rose® in reducing delayed repeated aspiration of the thyroid. A total of 120 cytological samples were collected and observed using Mobile Rose® after fine-needle aspiration cytology between September and Octob...
#1In-Hwa Park (Hanyang University)H-Index: 5
#2Guang-Yin Shen (JLU: Jilin University)
Last. Kyung Soo KimH-Index: 19
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Prolonged endoplasmic reticulum (ER) stress contributes to the apoptosis of cardiomyocytes, which leads to the development of diabetic cardiomyopathy. Previously, we reported that the granulocyte colony-stimulating factor (G-CSF) reduces the cardiomyocyte apoptosis in diabetic cardiomyopathy; however, the precise mechanisms associated with this process are not yet fully understood. Therefore, in this study, we investigated whether the mechanism of the anti-apoptotic effect of G-CSF was associate...
#1Yasufumi Enyama (Kanazawa University)H-Index: 1
#2Yumie Takeshita (Kanazawa University)H-Index: 20
Last. Toshinari Takamura (Kanazawa University)H-Index: 57
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This randomized, open-label, and parallel-group study aimed to investigate the effects of altering the timing of carbohydrate intake at breakfast or dinner on blood glucose fluctuations and energy metabolism. A total of 43 participants with type 2 diabetes were assigned to either the breakfast or dinner group. Participants were provided an isocaloric carbohydrate-restricted diet constituting 10% carbohydrate only at breakfast or dinner for 2 days during the study. Glucose fluctuations were compa...
#1Masumi Tamagawa (Keio: Keio University)H-Index: 1
#2Yoshifumi Kasuga (Keio: Keio University)H-Index: 8
Last. Mamoru Tanaka (Keio: Keio University)H-Index: 26
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Interventions for gestational diabetes mellitus (GDM), diagnosed in early pregnancy, have been a topic of controversy. This study aimed to elucidate factors that predict patients with GDM diagnosed before 24 gestational weeks (early GDM: E-GDM) who require insulin therapy later during pregnancy. Furthermore, we identified patients whose impaired glucose tolerance should be strictly controlled from early gestation onward. Women diagnosed with GDM were categorized based on the gestational age at d...
#1Yu Mao (Zhengzhou University)H-Index: 2
#2Ya-Jie Huo (Zhengzhou University)H-Index: 1
Last. Zhiqiang Kang (Zhengzhou University)H-Index: 2
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Circular RNA 40S ribosomal protein S28 (circRPS28; hsa_circ_0049055) is upregulated in papillary thyroid carcinoma (PTC) patients. However, its role remained uncovered in the progression of PTC. Above all, expression of circRPS28 was determined in PTC samples by real-time quantitative PCR and circRPS28 was highly expressed in tumor tissues and cells. Besides, circRPS28 was predominantly distributed in the cytoplasm. Functional experiments were launched using colony formation assay, 3-(4,5-dimeth...
Top fields of study
Diabetes mellitus