Cell differentiation is disrupted by MYO5B loss through Wnt/Notch imbalance
Abstract
Functional loss of myosin Vb (MYO5B) induces a variety of deficits in intestinal epithelial cell function and causes a congenital diarrheal disorder, microvillus inclusion disease (MVID). The impact of MYO5B loss on differentiated cell lineage choice has not been investigated. We quantified the populations of differentiated epithelial cells in tamoxifen-induced, epithelial cell-specific MYO5B-knockout (VilCreERT2 Myo5bfl/fl) mice utilizing...
Paper Details
Title
Cell differentiation is disrupted by MYO5B loss through Wnt/Notch imbalance
Published Date
Aug 23, 2021
Journal
Volume
6
Issue
16
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