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6.21
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1962
Papers 2619
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#1Annemieke Smet (University of Antwerp)H-Index: 22
#2Tom Breugelmans (University of Antwerp)H-Index: 17
Last. Surbhi Malhotra-Kumar (University of Antwerp)H-Index: 35
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BACKGROUND SARS-CoV-2 infection induces mucin overexpression further promoting disease. As mucins are critical components of the innate immunity, unravelling their expression profiles that dictate the course of disease could greatly enhance our understanding and management of COVID-19. METHODS Using validated RT-PCR assays, we assessed mucin mRNA expression in the blood of symptomatic COVID-19 patients compared to symptomatic non-COVID-19 patients and healthy controls and correlated the data to ...
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#1Iuliia M. Gilchuk (VUMC: Vanderbilt University Medical Center)H-Index: 6
#2Sandhya Bangaru (VUMC: Vanderbilt University Medical Center)H-Index: 13
Last. James E. Crowe (VUMC: Vanderbilt University Medical Center)H-Index: 91
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Avian H7N9 influenza viruses cause sporadic outbreaks of human infections and threaten to cause a major pandemic. The breadth of B cell responses to natural infection and the dominant antigenic sites recognized during first exposure to H7 HA following infection are incompletely understood. Here, we studied the B cell response to H7 HA of two individuals who had recovered from natural H7N9 virus infection. We used competition-binding, hydrogen-deuterium mass spectrometry, and single-particle nega...
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#1Janelle Geist Hauserman (UMB: University of Maryland, Baltimore)
#2Janis Stavusis (Latvian Biomedical Research and Study centre)H-Index: 5
Last. Kerry S. McDonald (MU: University of Missouri)H-Index: 20
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Myosin Binding Protein-C slow (sMyBP-C) comprises a subfamily of cytoskeletal proteins encoded by MYBPC1 that is expressed in skeletal muscles where it contributes to myosin thick filament stabilization and actomyosin cross-bridge regulation. Recently, our group described the causal association of dominant missense pathogenic variants in MYBPC1 with an early-onset myopathy characterized by generalized muscle weakness, hypotonia, dysmorphia, skeletal deformities, and myogenic tremor occurring in ...
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#1Patrice Fort (UM: University of Michigan)H-Index: 58
#2Thekkelnaycke M. Rajendiran (UM: University of Michigan)H-Index: 17
Last. Jerome E. Roger (Université Paris-Saclay)H-Index: 14
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BACKGROUND This study systematically investigated circulating and retinal tissue lipid determinants of human diabetic retinopathy (DR) to identify underlying lipid alterations associated with severity of DR. METHODS Retinal tissues were retrieved from postmortem human eyes including 19 individuals without diabetes, 20 with diabetes but without DR, and 20 with diabetes and DR for lipidomic study. In a parallel study, serum samples from 28 American Indians with type 2 diabetes from the Glia River ...
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Repetitive mild traumatic brain injuries (mTBI) disrupt central nervous system (CNS) barriers, the erosion of which has been linked to long-term neurodegenerative and psychiatric conditions. Although much attention has been devoted to CNS vasculature following mTBI, little is known about the glia limitans superficialis - a barrier of surface-associated astrocytes that helps protect the CNS parenchyma and maintain homeostasis. Here, we identify the glia limitans superficialis as a crucial barrier...
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#1Xinfang Xie (NU: Northwestern University)H-Index: 2
#2Li Gao (NU: Northwestern University)H-Index: 1
Last. Jing Jin (NU: Northwestern University)H-Index: 38
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IgA nephropathy is caused by deposition of circulatory IgA1 in the kidney. Hypo-galactosylated IgA1 has the propensity to form poly-IgA aggregates that are prone to deposition. We purified poly-IgA from the plasma of IgA nephrology patients and showed the complex being susceptible to reducing condition, suggesting intermolecular disulfide connections between IgA units. We sought to find the cysteine residue(s) in forming intermolecular disulfide. Naturally assembled dimeric IgA, also known as se...
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#1Miriam Y. KimH-Index: 9
#2Matthew L. CooperH-Index: 15
Last. John F. DiPersioH-Index: 108
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Targeting T cell malignancies with universal CD7-targeting chimeric antigen receptor T cells (UCART7) can lead to profound immune deficiency due to loss of normal T and NK cells. While a small population of endogenous CD7- T cells exists, these cells are unlikely to be able to repopulate the entire immune repertoire after UCART7 treatment, as they are limited in number and proliferative capacity. To rescue T and NK cells after UCART7, we created hematopoietic stem cells genetically deleted for C...
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#1Zhihong Yang (IU: Indiana University)H-Index: 20
#2Rana Smalling (VUMC: Vanderbilt University Medical Center)H-Index: 1
Last. Sen Han (IU: Indiana University)H-Index: 3
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Alcohol-associated liver disease (ALD) represents a spectrum of histopathological changes, including alcoholic steatosis, steatohepatitis, and cirrhosis. One of the early responses to excessive alcohol consumption is lipid accumulation in the hepatocytes. Lipid ω-hydroxylation of medium- and long-chain fatty acid metabolized by the cytochrome P450 4A (CYP4A) family is an alternative pathway for fatty acid metabolism. The molecular mechanisms of CYP4A in ALD pathogenesis have not been elucidated....
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#1Sujie Ke (UCLA: University of California, Los Angeles)
#2Yan-Yun Liu (UCLA: University of California, Los Angeles)H-Index: 14
Last. Gregory A. Brent (UCLA: University of California, Los Angeles)H-Index: 41
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Thyroid hormone receptor beta (THRB) is post-translationally modified by small ubiquitin-like modifier (SUMO). We generated a mouse model with a mutation that disrupts sumoylation at lysine 146 (K146Q) and resulted in desumoylated THRB as the predominant form in tissues. The THRB K146Q mutant mice had normal serum thyroxine (T4), markedly elevated serum thyrotropin (TSH) (81-fold above control), and enlargement of both the pituitary and the thyroid gland. The marked elevation in TSH, despite a n...
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#1Sean K. Wang (Harvard University)H-Index: 11
#2Yunlu XueH-Index: 8
Last. Constance L. CepkoH-Index: 107
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Inherited retinal diseases such as retinitis pigmentosa (RP) can be caused by thousands of different mutations, a small number of which have been successfully treated with gene replacement. However, this approach has yet to scale and may not be feasible in many cases, highlighting the need for interventions that could benefit more patients. Here, we found that microglial phagocytosis is upregulated during cone degeneration in RP, suggesting that expression of "don't eat me" signals such as CD47 ...
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