Delivered dose–effect analysis of radiation induced rib fractures after thoracic SBRT

Anatomical changes during the stereotactic body radiation therapy (SBRT) of early stage non-small cell lung cancer (NSCLC) may cause the delivered dose to deviate from the planned dose. We investigate if normal tissue complication probability (NTCP) models based on the delivered dose predict radiation-induced rib fractures better than models based on the planned dose.437 NSCLC patients treated to a median dose of 3x18 Gy were included. Delivered...