IMPACT OF DIFFERENT INDUCTION REGIMENS ON THE OUTCOME OF PRIMARY MEDIASTINAL B CELL LYMPHOMA IN THE PROSPECTIVE IELSG 37 TRIAL

Introduction: Primary mediastinal B-cell lymphoma (PMBCL) is characterized by poor prognosis if adequate responses are not rapidly achieved or if the disease recurs. Therefore, dose-intensive chemoimmunotherapy regimens are widely used but their superiority over the standard R-CHOP21 regimen has not been proven by randomized trials, furthermore they come with significant associated toxicities. Radiotherapy (RT) can consolidate responses after...