Original paper
Computational model of silica nanoparticle penetration into tumor spheroids: Effects of methoxy and carboxy PEG surface functionalization and hyperthermia
Volume: 37, Issue: 8
Published: Jun 24, 2021
Abstract
Drug delivery to tumors suffers from poor solubility, specificity, diffusion through the tumor micro‐environment and nonoptimal interactions with components of the extracellular matrix and cell surface receptors. Nanoparticles and drug–polymer complexes address many of these problems. However, large size exasperates the problem of slow diffusion through the tumor. Three‐dimensional tumor spheroids are good models to evaluate approaches to...
Paper Details
Title
Computational model of silica nanoparticle penetration into tumor spheroids: Effects of methoxy and carboxy PEG surface functionalization and hyperthermia
Published Date
Jun 24, 2021
Volume
37
Issue
8
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Notes
History