Computational model of silica nanoparticle penetration into tumor spheroids: Effects of methoxy and carboxy PEG surface functionalization and hyperthermia

Drug delivery to tumors suffers from poor solubility, specificity, diffusion through the tumor micro‐environment and nonoptimal interactions with components of the extracellular matrix and cell surface receptors. Nanoparticles and drug–polymer complexes address many of these problems. However, large size exasperates the problem of slow diffusion through the tumor. Three‐dimensional tumor spheroids are good models to evaluate approaches to...