Dihydromyricetin suppresses cell metastasis in human osteosarcoma through SP-1- and NF-κB-modulated urokinase plasminogen activator inhibition

Chia-Hsuan Chou; Ko-Hsiu Lu; Jia-Sin Yang; Yi-Hsien Hsieh; Chiao-Wen Lin; Shun-Fa Yang

doi:https://doi.org/10.1016/j.phymed.2021.153642

doi.org/10.1016/j.phymed.2021.153642

Dihydromyricetin suppresses cell metastasis in human osteosarcoma through SP-1- and NF-κB-modulated urokinase plasminogen activator inhibition

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..., Shun-Fa Yang

53

Phytomedicine7.90

Volume: 90, Pages: 153642 - 153642

Published: Sep 1, 2021

Abstract

Metastasis caused a decline in the 5-years survival rate of osteosarcoma. Therefore, developing new targeted therapeutics for osteosarcoma treatment is imperative. Dihydromyricetin (DHM) has several physiological functions: it counteracts inflammation, oxidation, and antitumor properties. However, the effects of DHM on osteosarcoma and its underlying mechanisms are still not well understood.In this study, we investigated the antimetastatic...

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Paper Details

Title

Dihydromyricetin suppresses cell metastasis in human osteosarcoma through SP-1- and NF-κB-modulated urokinase plasminogen activator inhibition

DOI

doi.org/10.1016/j.phymed.2021.153642

Published Date

Sep 1, 2021

Journal

Phytomedicine

Volume

90

Pages

153642 - 153642

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