Phytomedicine
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#1Xiao-Tian Qi (SDU: Shandong University)H-Index: 1
#2Jing Liu (SDU: Shandong University)
Last. Rong Sun (SDU: Shandong University)H-Index: 5
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Abstract Background : Despite granulocyte colony-stimulating factor (GCSF) is widely used in clinical, cancer chemotherapy induced neutropenia (CCIN) infection and infection-related mortality is high for lack of functionally mature neutrophils. Generating functional neutrophils is new therapeutic approaches to reduce CCIN-associated infection and mortality. Saikosaponin a (SSA) is one of the major bioactive components of Radix Bupleuri (RB) and exerts immunoregulatory effects. Purpose : The pres...
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#1Gang Chen (CAS: Chinese Academy of Sciences)
#2Wenhui Chang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Ning Li (SPU: Shenyang Pharmaceutical University)H-Index: 21
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Abstract Background : SiO2 nanoparticles (nm SiO2) are ubiquitous in daily life and are acknowledged to be detrimental to human health. Bletilla striata is a traditional medicine used for generations in China and its polysaccharide has the anti-pulmonary fibrosis effect. Purpose : To investigate the lung protective effect of the small molecules (n-BuOH extract) of B. striata and clarify the underlying mechanism. Study design and methods : C57BL/6 mice were subjected to intratracheal instillation...
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#1Yunlong Chen (Tianjin University of Traditional Chinese Medicine)H-Index: 2
#2Yan-Fang Xian (CUHK: The Chinese University of Hong Kong)H-Index: 22
Last. Zhi-Xiu Lin (CUHK: The Chinese University of Hong Kong)H-Index: 32
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Abstract Background : Dictamni Cortex (DC), a Chinese herbal medicine with wind dispelling and itchiness relieving effects, is the most popular single herb prescribed for the treatment of atopic dermatitis (AD), as it is used in up to 12.68% of all herbal prescriptions for AD. Purpose : The present study aimed to evaluate the anti-AD effect of Dictamni Cortex extract (DCE) and elucidate the underlying molecular mechanisms of its action using the 1-chloro-2,4-dinitrobenzene (DNCB)-induced AD-like...
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#1Jun-nan HuH-Index: 9
#2Jia-yu YangH-Index: 2
Last. Wei LiH-Index: 22
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Abstract Background Cisplatin is one of the most common chemotherapeutic drugs. Cisplatin-induced toxicity gives rise to gastrointestinal cell damage, subsequent diarrhea and vomiting, leading to the discontinuation of its clinical application in long-term cancer chemotherapy. Panax quinquefolium L., also known as American ginseng, has many pharmacological activities such as improving immunity, anti-tumor, anti-radiation and blood sugar lowering. Purpose Previously, our laboratory reported that ...
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#1Jing Ni (Tongji University)H-Index: 2
#2Yuanmin Li (Tongji University)H-Index: 4
Last. Rong Guo (Tongji University)H-Index: 12
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Abstract Background : Diabetic cardiomyopathy is characterized by both systolic and diastolic dysfunction due to decreased contractility, as well as reduced compliance of the myocardium. Oxidative stress plays a significant role in diabetes mellitus and its cardiovascular complications. Salidroside, a glucoside of the phenylpropanoid tyrosol, reportedly increases the levels of the antioxidative enzymes, nuclear factor erythroid 2-related factor 2, and heme oxygenase-1 (HO-1) to counteract oxidat...
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#1Da-Hye Lee (UST: Korea University of Science and Technology)H-Index: 7
#2So-Hyun Park (UST: Korea University of Science and Technology)H-Index: 3
Last. Chang Hwa Jung (UST: Korea University of Science and Technology)H-Index: 9
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Abstract Background : The enhancement of energy expenditure has attracted attention as a therapeutic target for the management of body weight. Withaferin A (WFA), a major constituent of Withania somnifera extract, has been reported to possess anti-obesity properties, however the underlying mechanism remains unknown. Purpose : To investigate whether WFA exerts anti-obesity effects via increased energy expenditure, and if so, to characterize the underlying pathway. Methods : C57BL/6J mice were fed...
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#1Ching-Chieh Kao (KMU: Kaohsiung Medical University)
#2Po-Hsiung Kung (KMU: Kaohsiung Medical University)H-Index: 1
Last. Chin-Chung Wu (KMU: Kaohsiung Medical University)H-Index: 12
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Abstract Background/Purpose: Juglone, a natural compound widely found in Juglandaceae plants, has been suggested as a potential drug candidate for treating cancer, inflammation, and diabetic vascular complications. In the present study, the antiplatelet effect and underlying mechanisms of juglone were investigated for the first time. Study design/methods: Human platelet aggregation and activation were measured by turbidimetric aggregometry, flow cytometry, and Western blotting. In vitro antithro...
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#1Wei-Chung Hsu (Asia University (Japan))
Last. Chih Yang HuangH-Index: 42
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Abstract Background Chemoresistance remains the main obstacle in hepatocellular carcinoma (HCC) therapy. Despite significant advances in HCC therapy, HCC still has a poor prognosis. Thus, there is an urgent need to identify a treatment target to reverse HCC chemotherapy resistance. Platycodon grandiflorus (PG) is a perennial herb that has been used as food and traditional Chinese medicine for thousands of years in Northeast Asia. Platycodin D (PD), a main active triterpenoid saponin found in the...
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#1Chaoyun Wang (Binzhou University)H-Index: 5
#2Hongzhi Wan (Binzhou University)H-Index: 1
Last. Chunxiang Zhang (UAB: University of Alabama at Birmingham)H-Index: 10
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Abstract Background Oxidative stress induces mitochondrial dysfunction, causing memory loss. Long noncoding RNAs influence mitochondrial function and suppress oxidative stress by regulating target protein expression and gene transcription. Celastrol, a natural antioxidant extracted from Tripterygium wilfordii Hook F. (“Thunder of God Vine”), effectively alleviates oxidative stress-mediated tissue injury. In the present study, we examined the effects of celastrol on memory dysfunction induced by ...
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#1Chengqiang Wang (SWU: Southwest University)H-Index: 5
#2Gen Liu (SWU: Southwest University)H-Index: 2
Last. Hongyi Qi (SWU: Southwest University)H-Index: 9
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Abstract Background Acute myeloid leukemia (AML) is a devastating hematologic malignancy with a high mortality. The nuclear receptors Nur77 and NOR-1 are commonly downregulated in human AML blasts and have emerged as key therapeutic targets for AML. Methods This study aimed to identify Z-ligustilide (Z-LIG), the main phthalide of Rhizoma Chuanxiong, as a potential agent that can selectively target AML. The anti-AML activity of Z-LIG was evaluated in vitro and in vivo, and the effect and underlyi...
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