Identification of anti‐Parkinson's Disease Lead Compounds from Aspergillus ochraceus Targeting Adenosin Receptors A2A
Abstract
Two novel alkaloids compounds together with fifteen know metabolites were identified from Aspergillus ochraceus . The stereochemistry features of the new molecules were determined via HRESIMS, NMR, ECD, and XRD analyses. Amongst these, compounds two compounds exhibited potential efficacy as anti‐Parkinson's disease with the EC 50 values of 2.30 and 2.45 μ M , respectively. ADMET prediction showed that these compounds owned favorable drug‐like...
Paper Details
Title
Identification of anti‐Parkinson's Disease Lead Compounds from Aspergillus ochraceus Targeting Adenosin Receptors A2A
Published Date
Jun 1, 2021
Journal
Volume
10
Issue
6
Pages
630 - 638
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