Functional MYO5B Loss Disrupts Stem Cell Function and Differentiation of Secretory Cell Lineage

Background and Aims Differentiation of intestinal epithelial cells involves cell division inhibition, cell lineage choice, and brush border elaboration. Functional myosin Vb (MYO5B) loss causes microvillus inclusion disease (MVID) and induces a variety of deficits in enterocyte function. However, the impact of MYO5B loss on differentiated cell lineage choice had not been investigated. Since intestinal progenitor cells predominantly express...