The protective effect of early dietary fat consumption on Alzheimer's disease–related pathology and cognitive function in mice

It has been suggested that obesity may influence Alzheimer's disease (AD) pathogenesis, yet the numerous publications on this topic have inconsistent results and conclusions.Our study examined the effect of varying the timing of high-fat diet (HFD) consumption on AD-related pathology and cognition in transgenic Tg6799 AD mice.HFD feeding starting at or before 3 months of age, prior to severe AD pathology, had protective effects in AD mice:...