Alzheimer's & Dementia: Translational Research & Clinical Interventions
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#1Joost D. Wammes (PHRI: Public Health Research Institute)H-Index: 1
#2Nanon Labrie (VU: VU University Amsterdam)H-Index: 2
Last. Janet L. MacNeil Vroomen (PHRI: Public Health Research Institute)H-Index: 1
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#1Yian GuH-Index: 28
#2Jing Guo (Columbia University)
Last. Alanna J. Moshfegh (ARS: Agricultural Research Service)H-Index: 30
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Introduction It is unclear whether the association between Mediterranean-type Diet (MeDi) and cognition is similar across different racial/ethnic groups or between women and men. Methods The current study included 2435 participants (≥60 years of age) of the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Linear regression models were applied to examine the association between diet and cognition, adjusted for multiple demographic variables. Interaction between MeDi and race/e...
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#1Dawn C. MatthewsH-Index: 10
#2Aaron Ritter (Lou Ruvo Brain Institute)H-Index: 10
Last. Jeffrey L. Cummings (UNLV: University of Nevada, Las Vegas)H-Index: 166
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Background A Phase II proof of concept (POC) randomized clinical trial was conducted to evaluate the effects of rasagiline, a monoamine oxidase B (MAO-B) inhibitor approved for Parkinson disease, in mild to moderate Alzheimer's disease (AD). The primary objective was to determine if 1 mg of rasagiline daily for 24 weeks is associated with improved regional brain metabolism (fluorodeoxyglucose-positron emission tomography [FDG-PET]) compared to placebo. Secondary objectives included measurement o...
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#1Jessica Samuelsson (University of Gothenburg)H-Index: 2
#2Silke Kern (University of Gothenburg)H-Index: 19
Last. Anna Zettergren (University of Gothenburg)H-Index: 13
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Background Diet may be a modifiable factor for reducing the risk of Alzheimer's disease (AD). Western-style dietary patterns are considered to increase the risk, whereas Mediterranean-style dietary patterns are considered to reduce the risk. An association between diet and AD-related biomarkers have been suggested, but studies are limited. Aim To investigate potential relations between dietary patterns and cerebrospinal fluid (CSF) biomarkers for AD among dementia-free older adults. Methods Data...
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#1Susanne Röhr (Trinity College, Dublin)H-Index: 2
#1Susanne Röhr (Leipzig University)H-Index: 10
Last. Mark A. Espeland (Wake Forest University)H-Index: 91
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Abstract Introduction The coronavirus disease-19 (COVID-19) pandemic presents challenges to the conduct of randomized clinical trials of lifestyle interventions Methods World-Wide FINGERS is an international network of clinical trials to assess the impact of multidomain lifestyle intervention on cognitive decline in at-risk adults Individual trials are tailoring successful approaches from the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) to local cu...
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#1Anna Amelianchik (Rockefeller University)
#2Jonathan Merkel (Rockefeller University)
Last. Erin H. Norris (Rockefeller University)H-Index: 27
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Introduction It has been suggested that obesity may influence Alzheimer's disease (AD) pathogenesis, yet the numerous publications on this topic have inconsistent results and conclusions. Methods Our study examined the effect of varying the timing of high-fat diet (HFD) consumption on AD-related pathology and cognition in transgenic Tg6799 AD mice. Results HFD feeding starting at or before 3 months of age, prior to severe AD pathology, had protective effects in AD mice: reduced extracellular amy...
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#1Arenda Mank (VUmc: VU University Medical Center)
#2Ingrid S. van Maurik (VU: VU University Amsterdam)H-Index: 9
Last. Philip Scheltens (VUmc: VU University Medical Center)H-Index: 155
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Elderly persons with currently normal cognition who have cerebral hypometabolism as shown by low uptake of 18fluorine-fluorodeoxyglucose (18F-FDG), are at risk of future loss of cognition and, thus, of future Alzheimer's dementia (AD). Reduction of either 18F-FDG or cognition is assumed to reflect synaptic dysfunction, since synapses account for the majority of glucose use by the brain and cognition depends upon accurate synaptic function. The chronology of the connection between reduced cerebra...
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Introduction null A previous phase 2b study supported the use of the 5-HT6 receptor antagonist intepirdine as adjunctive therapy to donepezil for Alzheimer's disease (AD) dementia. A phase 3 study, MINDSET, was performed to test this hypothesis. null Methods null MINDSET was a global, double-blind, randomized, placebo-controlled trial in 1315 mild-to-moderate AD dementia patients on stable donepezil. Patients received 35 mg/day intepirdine or placebo for 24 weeks. The co-primary endpoints were c...
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#1Marissa D. Zwan (UvA: University of Amsterdam)H-Index: 8
#1Marissa D Zwan (UvA: University of Amsterdam)H-Index: 1
Last. Niels D. Prins (UvA: University of Amsterdam)H-Index: 1
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Introduction The Dutch Brain Research Registry aims to facilitate online recruitment of participants for brain disease studies. Methods Registrants were primarily recruited through an online social media campaign. The registration process included a short questionnaire, which was subsequently used in the prescreening process to match participants to studies. Results In the first 18 months, 17,218 registrants signed up (58±11 years old, 78% female). Out of 34,696 study invitations that were sent,...
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