Batch enrollment for an artificial intelligence-guided intervention to lower neurologic events in patients with undiagnosed atrial fibrillation: rationale and design of a digital clinical trial

• The BEAGLE study will employ digital technologies and other pragmatic features designed to improve the efficiency of clinical trials. • These features include: • ``Siteless'' design in which enrollment, intervention, and follow-up are conducted remotely. • Video-based enrollment and study consent processes. • Testing of a novel AI-ECG algorithm as well as automated EHR-based NLP algorithms for the detection of previously undiagnosed AF among...