American Heart Journal
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#1Nima Moghaddam (UBC: University of British Columbia)H-Index: 2
#2Navraj Malhi (UBC: University of British Columbia)H-Index: 4
Last. Mustafa Toma (St. Paul's Hospital)H-Index: 14
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Abstract null null Background null Soluble guanylate cyclase (sGC) stimulators are a novel class of medications with emerging role in heart failure (HF). The aim of this study is to evaluate the efficacy and safety of oral sGC stimulators in patients with HF with reduced and preserved ejection fraction (HFrEF and HFpEF) by pooling data from all available randomized control trials (RCT). null null null Methods null A comprehensive search of electronic databases from 2000-2020 was performed. Seven...
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#1Jonathan J. Edwards (Children's Hospital of Philadelphia)H-Index: 6
#2Jonathan B Edelson (Children's Hospital of Philadelphia)H-Index: 2
Last. Joyce Wald (UPenn: University of Pennsylvania)H-Index: 18
view all 21 authors...
Abstract null null There are limited data describing the prevalence of mental health disorders (MHDOs) in patients with ventricular assist devices (VADs), or associations between MHDOs and resource use or outcomes. We used the Nationwide Emergency Department Sample administrative database to analyze 44,041 ED encounters for VAD-supported adults from 2010 to 2017, to assess the relationship between MHDOs and outcomes in this population. MHDO diagnoses were present for 23% of encounters, and were ...
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#1Veraprapas Kittipibul (JMH: Jackson Memorial Hospital)H-Index: 5
#2Vanessa Blumer (Duke University)H-Index: 7
Last. Richa Agarwal (Duke University)H-Index: 8
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Background Right ventricular failure (RVF) remains a major cause of morbidity and mortality after left ventricular assist device (LVAD). Atrial fibrillation (AF) is known for its deleterious effects on cardiac function and hemodynamics. The association of pre-operative AF with the risk of early post-LVAD RVF has not been well described. Method A comprehensive literature search was performed through April, 9 2021. Cohort studies comparing the risk of post-operative RVF and/or need for right ventr...
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#1Carlos E. Barbery (Duke University)
#2Anna Giczewska (Duke University)H-Index: 3
Last. W. Schuyler Jones (Duke University)H-Index: 27
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Cardiovascular (CV) outcome studies of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shifted the paradigm of type 2 diabetes management given their benefits regarding a reduction in major adverse CV events. However, the relationship between GLP-1 RAs and coronary revascularization remains poorly understood. In this EXSCEL post-hoc analysis, we used univariate Cox proportional models and Kaplan Meier survival analysis to evaluate the effect of once-weekly exenatide (EQW) on a composi...
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#1Aayushi Joshi (McGill University)H-Index: 1
#2Rita Mancini (McGill University)H-Index: 1
Last. Jonathan Afilalo (McGill University)H-Index: 38
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ABSTRACT Background To determine the prevalence and prognostic value of sarcopenia measured by dual x-ray absorptiometry (DXA) and physical performance tests in patients undergoing coronary artery bypass surgery or heart valve procedures. Methods Adults undergoing cardiac surgery were prospectively enrolled and completed a questionnaire, physical performance battery, and a DXA scan (GE Lunar) to measure appendicular muscle mass indexed to height 2 (AMMI). Patients were categorized as sarcopenic ...
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#1Marcelo Rodrigues dos Santos (USP: University of São Paulo)H-Index: 12
#2Maria-Janieire N. N. Alves (USP: University of São Paulo)H-Index: 8
Last. Antonio Carlos Pereira Barretto (USP: University of São Paulo)H-Index: 32
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BACKGROUND Sacubitril/valsartan reduces mortality in patients with heart failure with reduced ejection fraction (HFrEF) when compared with enalapril. However, it is unknown the effect of both treatments on exercise capacity. We compared sacubitril/valsartan versus enalapril in patients with HFrEF based on peak oxygen consumption (VO2) and 6-minute walk test (6-MWT). METHODS We included 52 participants with HFrEF with a left ventricular ejection fraction <40% to receive either sacubitril/valsarta...
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#1Kenneth C. Bilchick (University of Virginia Health System)H-Index: 11
#2Patrick Stafford (University of Virginia Health System)
Last. Anita Barber (University of Virginia Health System)
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Abstract null null Background null The prognostic importance of trajectories of neurohormones relative to left ventricular function over time in heart failure with reduced and mid-range EF (HFrEF and HFmrEF) is poorly defined. null null null Objective null To evaluate left ventricular ejection fraction (LVEF) and B-type natriuretic peptide (BNP) trajectories in HFrEF and HFmrEF. null null null Methods null Analyses of LVEF and BNP trajectories after incident HF admissions presenting with abnorma...
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#1Ghadeer K. Dawwas (Leonard Davis Institute of Health Economics)H-Index: 5
#2Geoffrey D. Barnes (UM: University of Michigan)H-Index: 15
Last. James D. LewisH-Index: 105
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ABSTRACT null null Background: Direct oral anticoagulants (DOACs) are replacing warfarin for stroke prevention in patients with atrial fibrillation (AF). null Objective: To assess the effectiveness and safety of concomitant treatment with antiplatelet-DOAC compared to antiplatelet-warfarin in patients with ACS and AF. null Design: Retrospective propensity score-matched cohort study using United States-based commercial healthcare database from January 2016 to June 2019. null Participants: New-use...
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#1Mohammad Alkhalil (Freeman Hospital)
#2Gavin Thomas (Ulster Hospital)
Last. Peter McKavanagh (Ulster Hospital)H-Index: 6
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BACKGROUND The significant difference in the proportion of female patients included in the registry and randomized cohorts in the FAME-2 trial remains poorly understood. Fractional Flow Reserve (FFR) is influenced by the size of subtended myocardium. Sex-based difference in FFR values may be related to this phenomenon. We hypothesised that FFR of proximal lesions (surrogate of large myocardium) differed according to sex and this would translate into difference in clinical outcomes. Such differen...
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#1Mathias Pinto Bonnesen (Copenhagen University Hospital)
#2Søren Zöga Diederichsen (Copenhagen University Hospital)H-Index: 9
Last. Lars Køber (Copenhagen University Hospital)H-Index: 128
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ABSTRACT null null Aims null To study the relationship between subclinical atrial fibrillation (AF) and changes in cognitive function in a large cohort of individuals with stroke risk factors. null null null Methods null : Individuals with no prior AF diagnosis but with risk factors for stroke were recruited to undergo annual cognitive assessment with the Montreal Cognitive Assessment (MoCA) along with implantable loop recorder (ILR) monitoring for AF for 3 years. If AF episodes lasting ≥6 minut...
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