American Heart Journal
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#1Megan Lee (Yale University)
#2Zain Ahmed (Yale University)H-Index: 1
Last. Carlos Mena-Hurtado (Yale University)H-Index: 11
view all 8 authors...
Abstract null null For those undergoing peripheral vascular interventions (PVI), guidelines indicate the use of dual antiplatelet therapy (DAPT) is reasonable (Class IIb), but recommendations have not reached the highest level of evidence. In the largest effort to date, we found that antithrombotic prescription was dominated by single antiplatelet therapy (SAPT) (51.4%) before PVI, which switched to DAPT (57.7%) following PVI, with some patients still remaining on no therapy (8%). High site vari...
#1Adel AminianH-Index: 21
#2Gregory A. SguegliaH-Index: 23
Last. Sasko KedevH-Index: 22
view all 17 authors...
Abstract null null Background null Transradial access (TRA) has become the default access method for coronary diagnostic and interventional procedures. As compared to transfemoral access, TRA has been shown to be safer, cost-effective and more patient-friendly. Radial artery occlusion (RAO) represents the most frequent complication of TRA, and precludes future coronary procedures through the radial artery, the use of the radial artery as a conduit for coronary artery bypass grafting or as arteri...
#1Neha K. Reddy (NU: Northwestern University)H-Index: 3
#2Vaidehi Kaushal (Emory University)
Last. Nilay S. Shah (NU: Northwestern University)H-Index: 7
view all 6 authors...
South Asians in the United States have disproportionately high burden of cardiovascular disease compared to other race/ethnic groups but are a heterogenous population, so we evaluated differences in prevalence and adjusted odds of cardiovascular risk factors including diabetes, hypertension, dyslipidemia, and obesity between North Indian, South Indian, and Pakistani immigrants in the United States in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. Given cultura...
#1Gillian M. Blue (Children's Hospital at Westmead)H-Index: 16
#2Mauk Mekel (VU: VU Amsterdam)
Last. Gary F. Sholler (Children's Hospital at Westmead)H-Index: 30
view all 17 authors...
Background null The most common cyanotic congenital heart disease (CHD) requiring management as a neonate is transposition of great arteries (TGA). Clinically, up to 50% of TGA patients develop some form of neurodevelopmental disability (NDD), thought to have a significant genetic component. A 'ciliopathy' and links with laterality disorders have been proposed. This first report of whole genome sequencing (WGS) in TGA, sought to identify clinically relevant variants contributing to heart, brain ...
#1Miguel Cainzos-Achirica (Houston Methodist)H-Index: 10
#2Dixitha Anugula (Creighton University)H-Index: 4
Last. Kausik K. Ray (Imperial College London)H-Index: 86
view all 12 authors...
ABSTRACT null null The Food and Drug Administration recommends prognostic enrichment of randomized controlled trials (RCTs), aimed at restricting the study population to participants most likely to have events and therefore derive benefit from a given intervention. The coronary artery calcium (CAC) score is powerful discriminator of cardiovascular risk, and in this review we discuss how CAC may be used to augment widely used prognostic enrichment paradigms of RCTs of add-on therapies in primary ...
#1Jorge Plutzky (BWH: Brigham and Women's Hospital)H-Index: 73
#2Mark D. Benson (BWH: Brigham and Women's Hospital)H-Index: 12
Last. Anton Dodek (BCBSMA: Blue Cross Blue Shield of Massachusetts)H-Index: 4
view all 14 authors...
Abstract null null Background null Implementation of guideline-directed cholesterol management remains low despite definitive evidence establishing their reduction of cardiovascular (CV) events, especially in high atherosclerotic CV disease (ASCVD) risk patients. Modern electronic resources now exist that may help improve health care delivery. While electronic medical records (EMR) allow for population health screening, the potential for coupling EMR screening to remotely delivered algorithmic p...
#1Kenneth C. Bilchick (University of Virginia Health System)H-Index: 11
#2Patrick Stafford (University of Virginia Health System)H-Index: 1
Last. Anita Barber (University of Virginia Health System)
view all 15 authors...
Abstract null null Background null The prognostic importance of trajectories of neurohormones relative to left ventricular function over time in heart failure with reduced and mid-range EF (HFrEF and HFmrEF) is poorly defined. null null null Objective null To evaluate left ventricular ejection fraction (LVEF) and B-type natriuretic peptide (BNP) trajectories in HFrEF and HFmrEF. null null null Methods null Analyses of LVEF and BNP trajectories after incident HF admissions presenting with abnorma...
#1Tyson Burnham (UU: University of Utah)H-Index: 1
#2Heidi T May (Intermountain Medical Center)H-Index: 40
Last. Joseph B. Muhlestein (UU: University of Utah)H-Index: 77
view all 14 authors...
BACKGROUND Class 1C antiarrhythmic drugs (AAD) have been associated with harm in patients treated for ventricular arrhythmias with a prior myocardial infarction. Consensus guidelines have advocated that these drugs not be used in patients with stable coronary artery disease (CAD). However, long-term data are lacking to know if unique risks exist when these drugs are used for atrial fibrillation (AF) in patients with CAD without a prior myocardial infarction. METHODS In 24,315 patients treated wi...
#1Kevin R. Bainey (University of Alberta)H-Index: 20
#2Jerome L. Fleg (NIH: National Institutes of Health)H-Index: 98
Last. Kian Keong Poh (NUS: National University of Singapore)H-Index: 28
view all 19 authors...
BACKGROUND The ISCHEMIA-CKD (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches-Chronic Kidney Disease) trial found no advantage to an invasive strategy compared to conservative management in reducing all-cause death or myocardial infarction (D/MI). However, the prognostic influence of angiographic coronary artery disease (CAD) burden and ischemia severity remains unknown in this population. We compared the relative impact of CAD extent and severity of m...
#1Marie-Sophie Louise Yvonne de Koning (UMCG: University Medical Center Groningen)H-Index: 2
#2Paulien van Dorp (UMCG: University Medical Center Groningen)
Last. Harry van Goor (UMCG: University Medical Center Groningen)H-Index: 91
view all 15 authors...
Abstract null null Rationale null Ischemia and subsequent reperfusion cause myocardial injury in patients presenting with ST-segment elevation myocardial infarction (STEMI). Hydrogen sulfide (H2S) reduces “ischemia-reperfusion injury” in various experimental animal models, but has not been evaluated in humans. This trial will examine the efficacy and safety of the H2S-donor sodium thiosulfate (STS) in patients presenting with a STEMI. null null null Study design null The Groningen Intervention s...
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