Antihypoxic activity of the dry extract from Nepeta multifida L.

Published on Jun 4, 2021in Natural Product Research2.158
· DOI :10.1080/14786419.2021.1935932
Sources
Abstract
The antihypoxic effect of the Nepeta multifida L. dry extract was studied in experiments on white Wistar rats. The life span of animals was determined against the background of acute hypoxias: hypercapnic, hemic, and histotoxic ones. Using the model of acute hypobaric hypoxia/reoxygenation there was evaluated the content of ATP, lactic and pyruvic acids, TBA-active products, reduced glutathione, catalase activity in brain tissue. On the model of acute hypobaric hypoxia/reoxygenation, the content of ATP, lactic and pyruvic acids, reduced glutathione and catalase activity in brain tissue The N. multifida dry extract demonstrated antihypoxic effect at the doses comprised between 100 and 300 mg/kg increasing lifespan of animals in hypercapnic, hemic and histotoxic hypoxias. N. multifida decreases the manifestation of free-radical oxidation processes, increases the activity of the endogenic antioxidant system, and promotes the efficacy of tissue respiration and oxidative phosphorylation coupling in the brain of white rats in hypoxia/reoxygenation.
References15
Newest
#2Saeid Heidari-Soureshjani (Shahrekord University of Medical Sciences)H-Index: 5
Last. Mojtaba KhaksarianH-Index: 7
view all 5 authors...
Source
#1Natalie B. Riblet (Dartmouth College)H-Index: 5
#2Daniel J. Gottlieb (The Dartmouth Institute for Health Policy and Clinical Practice)H-Index: 87
Last. Brian Shiner (Dartmouth College)H-Index: 20
view all 7 authors...
ABSTRACT The relationship between three markers of chronic hypoxia (altitude, smoking and chronic obstructive pulmonary disease (COPD)) and suicide risk has not been well-studied. We conducted a population-based cohort study evaluating the association between chronic hypoxia and suicide risk. Patients entered the cohort in their first year with a documented healthcare encounter and remained in the cohort until their death or the end of the study period. Generalized estimating equation (GEE) meth...
5 CitationsSource
#1Hai-Ying CuiH-Index: 4
#2Xiangjian ZhangH-Index: 35
Last. Rong ChenH-Index: 11
view all 7 authors...
Rosmarinic acid (RA) can elicit a neuroprotective effect against ischemic stroke, but the precise molecular mechanism remains poorly understood. In this study, an experimental ischemic stroke model was established in CD-1 mice (Beijing Vital River Laboratory Animal Technology, Beijing, China) by occluding the right middle cerebral artery for 1 hour and allowing reperfusion for 24 hours. After intraperitoneally injecting model mice with 10, 20, or 40 mg/kg RA, functional neurological deficits wer...
20 CitationsSource
#1Shami Kanekar (UofU: University of Utah)H-Index: 12
#2Chandni Sheth (UofU: University of Utah)H-Index: 7
Last. Perry F. RenshawH-Index: 104
view all 10 authors...
Abstract Treatment-resistant depression, a chronic condition that affects 30% of depressed patients on antidepressants, is highly linked to suicidal behavior. Chronic hypoxia exposure via living at altitude (hypobaric hypoxia) or with chronic hypoxic diseases is demographically linked to increased risk for depression and suicide. We previously demonstrated that housing rats at altitude for a week incrementally increases depression-like behavior in the forced swim test (FST) in females, but not m...
8 CitationsSource
#1Ya. G. RazuvaevaH-Index: 2
#2D.V. KhargeevH-Index: 1
Last. Daniil N. OlennikovH-Index: 20
view all 4 authors...
1 CitationsSource
#1Nora E. Gray (OHSU: Oregon Health & Science University)H-Index: 12
#2Armando Alcazar Magana (OSU: Oregon State University)H-Index: 6
Last. Amala Soumyanath (OHSU: Oregon Health & Science University)H-Index: 14
view all 8 authors...
This review describes in detail the phytochemistry and neurological effects of the medicinal herb Centella asiatica (L.) Urban. C. asiatica is a small perennial plant that grows in moist, tropical and sub-tropical regions throughout the world. Phytochemicals identified from C. asiatica to date include isoprenoids (sesquiterpenes, plant sterols, pentacyclic triterpenoids and saponins) and phenylpropanoid derivatives (eugenol derivatives, caffeoylquinic acids, and flavonoids). Contemporary methods...
35 CitationsSource
#1Jichun Han (Binzhou University)H-Index: 13
#2Dong Wang (SDU: Shandong University)H-Index: 14
Last. Qiusheng Zheng (Shihezi University)H-Index: 25
view all 11 authors...
The cardiac ischemia-reperfusion (I/R) injury greatly influences the therapeutic effect and remains an urgent challenge in clinical therapy. Polypharmacology opens a new therapeutic opportunity to design drugs with a specific target for improving the efficacy. In this study, we first forecasted that Rosmarinic acid (RosA) could be used for the treatment of cardiovascular disease using text mining, chemometric and chemogenomic methods. Consistent with the effect of the positive drug (pioglitazone...
29 CitationsSource
#1Dominik Szwajgier (University of Life Sciences in Lublin)H-Index: 15
#2Kamila Borowiec (University of Life Sciences in Lublin)H-Index: 5
Last. Katarzyna Pustelniak (University of Life Sciences in Lublin)H-Index: 1
view all 3 authors...
The neuroprotective role of phenolic acids from food has previously been reported by many authors. In this review, the role of phenolic acids in ameliorating depression, ischemia/reperfusion injury, neuroinflammation, apoptosis, glutamate-induced toxicity, epilepsy, imbalance after traumatic brain injury, hyperinsulinemia-induced memory impairment, hearing and vision disturbances, Parkinson’s disease, Huntington’s disease, anti-amyotrophic lateral sclerosis, Chagas disease and other less distrib...
70 CitationsSource
#1Dharambir Kashyap (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 18
#2Hardeep Singh Tuli (Maharishi Markandeshwar University, Mullana)H-Index: 25
Last. Anil K. Sharma (Maharishi Markandeshwar University, Mullana)H-Index: 32
view all 3 authors...
Plants are known to produce a variety of bioactive metabolites which are being used to cure various life threatening and chronic diseases. The molecular mechanism of action of such bioactive molecules, may open up new avenues for the scientific community to develop or improve novel therapeutic approaches to tackle dreadful diseases such as cancer and cardiovascular and neurodegenerative disorders. Ursolic acid (UA) is one among the categories of such plant-based therapeutic metabolites having mu...
139 CitationsSource
#1Leandra Naira Zambelli Ramalho (USP: University of São Paulo)H-Index: 29
#2Ângelo Augusto C. Pasta (USP: University of São Paulo)H-Index: 1
Last. Fernando Silva Ramalho (USP: University of São Paulo)H-Index: 26
view all 9 authors...
Abstract Rosmarinic acid (RosmA) demonstrates antioxidant and anti-inflammatory properties. We investigated the effect of RosmA on liver ischemia/reperfusion injury. Rats were submitted to 60 min of ischemia plus saline or RosmA treatment (150 mg/kg BW intraperitoneally) followed by 6 h of reperfusion. Hepatocellular injury was evaluated according to aminotransferase activity and histological damage. Hepatic neutrophil accumulation was also evaluated. Oxidative/nitrosative stress was estimated b...
26 CitationsSource
Cited By0
Newest