Activation of Vasopressin System During COVID-19 is Associated With Adverse Clinical Outcomes: An Observational Study

Activation of the vasopressin system plays a key role for the maintenance of osmotic, cardiovascular, and stress hormone homeostasis during disease. We investigated levels of copeptin, the C-terminal segment of the vasopressin prohormone, that mirrors the production rate of vasopressin in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).We measured levels of copeptin on admission and after days 3/4, 5/6, and...