Journal of the Endocrine Society
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Last. Alan D. Rogol (UVA: University of Virginia)H-Index: 97
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#1Huajing Ni (Concord Hospital)
#2Robert Schmidli (Canberra Hospital)H-Index: 1
Last. David J. Handelsman (Concord Hospital)H-Index: 105
view all 7 authors...
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#1Maria E. Bleil (UW: University of Washington)H-Index: 19
#2Bradley M. Appelhans (Rush University Medical Center)H-Index: 31
Last. Cathryn Booth-LaForce (UW: University of Washington)H-Index: 38
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#1Max Esefeld (QF: Qatar Foundation)
#2Antoni Pastor (UPF: Pompeu Fabra University)
Last. Karsten Suhre (QF: Qatar Foundation)H-Index: 80
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Objective null Administration of human growth hormone (hGH) is prohibited in competitive sport and its detection in an athlete's sample triggers an adverse analytical finding. However, the biological processes that are modulated by recombinant hGH are not well characterized and associated blood serum proteins may constitute new biomarkers for hGH misuse. null Methods null Thirty-five recreational athletes were enrolled in a study to investigate the time- and dose-dependent response of serum prot...
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#1Vijay Ramadoss (Imperial College Healthcare NHS Trust)H-Index: 1
#2Katharine Lazarus (Imperial College London)H-Index: 1
Last. Sirazum Choudhury (Imperial College London)H-Index: 5
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Background Adrenal Insufficiency (AI), especially iatrogenic-AI, is a treatable cause of mortality. The difficulty in obtaining 9 am cortisol levels means samples are taken at suboptimal times, including a substantial proportion in the afternoon. Low afternoon cortisol levels often provoke short Synacthen tests (SSTs). It is important that this does not lead to patients misdiagnosed with AI, exposing them to the excess mortality and morbidity of inappropriate steroid replacement therapy. Methods...
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#1Daniel A. Dumesic (UCLA: University of California, Los Angeles)H-Index: 63
#2Ayli Tulberg (UCLA: University of California, Los Angeles)H-Index: 1
Last. Gregorio D. Chazenbalk (UCLA: University of California, Los Angeles)H-Index: 52
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Context null Increased aldo-keto reductase 1C3 (AKR1C3)-mediated conversion of androstenedione (A4) to testosterone (T) promotes lipid storage in subcutaneous (SC) abdominal adipose in overweight/obese polycystic ovary syndrome (PCOS) women. null Objective null This work examines whether an elevated serum T/A4 ratio, as a marker of enhanced AKR1C3 activity in SC abdominal adipose, predicts metabolic function in normal-weight PCOS women. null Methods null This prospective cohort study took place ...
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#1Sabitha Sasidharan Pillai (Boston Children's Hospital)
#2Jose Bernardo Quintos (Boston Children's Hospital)H-Index: 13
Last. Lisa Swartz Topor (Boston Children's Hospital)H-Index: 8
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Background Hepatic glycogenosis (HG) has been reported after intravenous (IV) dextrose administration to treat insulin overdose. We describe a case of HG in a patient with type 1 diabetes mellitus (T1DM) due to insulin overdose treated with oral glucose administration. Case Presentation An adolescent boy with T1DM on a basal bolus insulin regimen presented with abdominal discomfort, nausea, vomiting, and hypoglycemia of a few hours. His glucose was 71 mg/dL, aspartate transaminase (AST) 119 U/L,...
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#1Yusuf Ali (UMMC: University of Mississippi Medical Center)
#2Maniselvan Kuppusamy (UMMC: University of Mississippi Medical Center)H-Index: 11
Last. Elise P. Gomez-Sanchez (UMMC: University of Mississippi Medical Center)H-Index: 52
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Affinity of the mineralocorticoid receptor (MR) is similar for aldosterone and the glucocorticoids (GC) cortisol and corticosterone, which circulate at concentrations far exceeding those of aldosterone. 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) inactivation of GC within the immediate vicinity of the MR is credited with prereceptor specificity for aldosterone in cells coexpressing MR and 11βHSD2. 11βHSD2 efficacy is also critical to other recently described 11βHSD2 substrates. The aim of ...
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#1Atsushi Yokoyama (Tohoku University)H-Index: 15
#2Takumi Kouketsu (Tohoku University)H-Index: 1
Last. Kazuhiko Igarashi (Tohoku University)H-Index: 74
view all 11 authors...
The androgen receptor (AR) plays an essential role in the development of prostate cancer, and androgen-deprivation therapy is used as a first-line treatment for prostate cancer. However, under androgen-deprivation therapy, castration-resistant prostate cancer inevitably arises, suggesting that the interacting transcriptional coregulators of AR are promising targets for developing novel therapeutics. In this study, we used novel proteomic techniques to evaluate the AR interactome, including bioch...
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