3D In Vitro Models for Investigating the Role of Stiffness in Cancer Invasion

Background: Tumorigenesis is attributed to the interactions of cancer cells with the tumor microenvironment through both biochemical cues and physical stimuli. Increased matrix deposition and realignment of the collagen fibers are detected by cancer cells, inducing epithelial-to-mesenchymal transition, which in turn stimulates cell motility and invasiveness. Methods: This review provides an overview of current research on the role of the...