ACS Biomaterials Science & Engineering
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#1Nicola Contessi Negrini (Imperial College London)
#2Ana Angelova Volponi ('KCL': King's College London)H-Index: 10
Last. Adam D. Celiz (Imperial College London)H-Index: 12
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Engineering cytocompatible hydrogels with tunable physico-mechanical properties as a biomimetic three-dimensional extracellular matrix (ECM) is fundamental to guide cell response and target tissue regeneration or development of in vitro models. Gelatin represents an optimal choice given its ECM biomimetic properties; however, gelatin cross-linking is required to ensure structural stability at physiological temperature (i.e., T > Tsol-gel gelatin). Here, we use a previously developed cross-linkin...
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#1Sahar Ansari (UCLA: University of California, Los Angeles)H-Index: 19
#2Sevda Pouraghaei Sevari (UCLA: University of California, Los Angeles)H-Index: 1
Last. Alireza Moshaverinia (UCLA: University of California, Los Angeles)H-Index: 25
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Soft tissue reconstruction has remained a major clinical challenge in dentistry and regenerative medicine. Although current methods have shown partial success, there are several disadvantages associated with these approaches. Gingival mesenchymal stem cells (GMSCs) can be simply obtained in the oral cavity for soft tissue augmentation. Regenerative potential of mesenchymal stem cells (MSCs) encapsulated in hydrogels is well documented. Here, an alginate-gelatin methacrylate (GelMA) hydrogel form...
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#1Auxtine Micalet (UCL: University College London)
#2Emad Moeendarbary (UCL: University College London)H-Index: 19
Last. Umber Cheema (UCL: University College London)H-Index: 24
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BACKGROUND Tumorigenesis is attributed to the interactions of cancer cells with the tumor microenvironment through both biochemical cues and physical stimuli. Increased matrix deposition and realignment of the collagen fibers are detected by cancer cells, inducing epithelial-to-mesenchymal transition, which in turn stimulates cell motility and invasiveness. METHODS This review provides an overview of current research on the role of the physical microenvironment in cancer invasion. This was achie...
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#1Di Liu (SU: Syracuse University)
#2Chao Chen (SU: Syracuse University)
Last. Teng Zhang (SU: Syracuse University)
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Understanding the structure-property relationship of biological materials, such as bones, teeth, cells, and biofilms, is critical for diagnosing diseases and developing bioinspired materials and structures. The intrinsic multiphase heterogeneity with interfaces places great challenges for mechanical modeling. Here, we develop an image-based polygonal lattice model for simulating the mechanical deformation of biological materials with complicated shapes and interfaces. The proposed lattice model ...
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#1Mariam Cherri (FU: Free University of Berlin)
#2Magda Ferraro (FU: Free University of Berlin)H-Index: 2
Last. Rainer Haag (FU: Free University of Berlin)H-Index: 88
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Targeted delivery and extended blood circulation of anticancer drugs have been the challenges for decreasing the adverse side effects and improving the therapeutic efficiency in cancer chemotherapy. Herein, we present a drug delivery system (DDS) based on biodegradable dendritic polyglycerol sulfate-bearing poly(caprolactone) (dPGS-PCL) chains, which has been synthesized on 20 g scale using a straightforward two-step protocol. In vivo fluorescence imaging demonstrated a significant accumulation ...
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#1Sunho Park (Chonnam National University)H-Index: 9
#2Yonghyun Gwon (Chonnam National University)H-Index: 4
Last. Jangho Kim (Chonnam National University)H-Index: 23
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Eggshell membrane (ESM)-based biomaterials have generated significant interest for their potential biomedical applications, including those in tissue engineering and regenerative medicine. Herein, the development of a bioactive ESM-based nanopatterned scaffold for enhancing the adhesion and functions of cells has been described. To control the shape of the raw ESM with entangled protein fibers, a two-step dissolution technique is used. Subsequently, nanoimprint lithography is applied to the ESM ...
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#1Aniruddha Adhikari (SNBNCBS: S.N. Bose National Centre for Basic Sciences)H-Index: 2
#2Susmita Mondal (SNBNCBS: S.N. Bose National Centre for Basic Sciences)H-Index: 4
Last. Samir Kumar Pal (SNBNCBS: S.N. Bose National Centre for Basic Sciences)H-Index: 59
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Precise control of intracellular redox status, i.e., maintenance of the physiological level of reactive oxygen species (ROS) for mediating normal cellular functions (oxidative eustress) while evading the excess ROS stress (distress), is central to the concept of redox medicine. In this regard, engineered nanoparticles with unique ROS generation, transition, and depletion functions have the potential to be the choice of redox therapeutics. However, it is always challenging to estimate whether ROS...
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#1Mehraneh Kermanian (Zanjan University of Medical Sciences)H-Index: 2
#2Somayeh Sadighian (Zanjan University of Medical Sciences)H-Index: 12
Last. Parviz Ghezelbash (Zanjan University of Medical Sciences)
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The present study introduces a superparamagnetic nanocomposite, Fe-Si-In, as a T2 magnetic resonance imaging (MRI) contrast agent with a core of iron oxide nanoparticles and a nonporous silica inner shell/carboxymethyl inulin outer shell. Due to its core/shell properties, the structure characterization, biocompatibility, and performance in MRI, as well as its potential as a drug delivery system, were thoroughly evaluated. The results have shown that the synthesized nanocomposite possesses excell...
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#1Maedeh Koohi Moftakhari Esfahani (QUT: Queensland University of Technology)H-Index: 12
#2Nazrul Islam (QUT: Queensland University of Technology)H-Index: 29
Last. Emad L. Izake (QUT: Queensland University of Technology)H-Index: 20
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Thiabendazole (TBZ) is an anthelmintic drug currently studied for anticancer purposes. However, due to its low solubility, its biomedical application has been limited. Using mesoporous silica nanoparticles (MSNPs), such as Mobil Composition of Matter Number 41 (MCM-41), as a drug carrier, is a promising approach to improve the solubility of low water-soluble drugs. In the present work, we aim to develop TBZ-loaded MCM-41 (TBZ MCM-41) nanoparticles to improve the solubility and the therapeutic ef...
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#1Lv Jianghong (SRRSH: Sir Run Run Shaw Hospital)
#2Meng Tingting (ZJU: Zhejiang University)
Last. Hu Fuqiang (ZJU: Zhejiang University)H-Index: 1
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Hepatocellular carcinoma (HCC) is known as the most common malignancy of the hepatobiliary system with a continued increase in incidence but limited therapeutic options. Nanomedicine has provided a promising strategy through engineered nanocarriers that are capable of targeting therapeutic agents specifically to tumor cells. In this research, two aptamer/peptide-modified lipid-based drug delivery systems (A54-PEG-SLN/OXA and A15-PEG-SLN/SAL) were developed as a sequential therapeutic strategy to...
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Top fields of study
Self-healing hydrogels
Biophysics
Biomedical engineering
Nanotechnology
Chemistry
Materials science
Tissue engineering