ACS Biomaterials Science & Engineering
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#1Rui Zan (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Hao Wang (Nantong University)
Last. Yongping Zhou (Nantong University)
view all 13 authors...
Biodegradable magnesium (Mg) implants spontaneously releasing therapeutic agents against tumors are an intriguing therapeutic approach for both tissue repair and tumor treatment. Anastomotic staples are extensively used for wound closure after surgical resection in patients with colorectal tumors. However, the safety of Mg anastomosis implants for intestinal closure and the effect of tumor suppression remain elusive. Here, we used a high-purity Mg staple to study these issues. Based on the resul...
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#1Jose R. Aguilar Cosme (University of Sheffield)H-Index: 2
#2Dan C Gagui (University of Sheffield)
Last. Frederik Claeyssens (University of Sheffield)H-Index: 33
view all 5 authors...
The evaluation of novel photosensitizers (PSs) for photodynamic therapy (PDT) is difficult due to the limitations of two-dimensional cell culture and multiple parameters (dose, light intensity, uptake time), which complicate progression to in vivo experiments and clinical translation. Three-dimensional (3D) cell culture models like multicellular cancer tumor spheroids (MCTS) show great similarities to in vivo avascular tumor conditions, improving the speed and accuracy of screening novel compoun...
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#1Mohsen Hosseini (VT: Virginia Tech)H-Index: 4
#2Saeed Behzadinasab (VT: Virginia Tech)H-Index: 2
Last. William A. Ducker (VT: Virginia Tech)H-Index: 51
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We developed antimicrobial coatings from ZnO particles that reduce the infectivity of SARS-CoV-2 suspensions by >99.9% in 1 h. The advantage of a coating is that it can be applied to a variety of objects, e.g., hand rails and door knobs, to hinder the spread of disease. Two porous coatings were prepared: one from submicrometer zinc oxide particles bound with silica menisci and the other from zinc oxide tetrapods bound with polyurethane. Experiments on glass coatings show that infectivity depends...
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#1Yan Dou (Tianjin Medical University General Hospital)H-Index: 2
#2Fangshi Zhao (Tianjin Medical University General Hospital)H-Index: 1
Last. Yanyan Guo (Tianjin Medical University)H-Index: 3
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Tumor heterogeneity leads to unpredictable radiotherapeutic outcomes although multiple sensitization strategies have been developed. Real-time monitoring of treatment response through noninvasive imaging methods is critical and a great challenge in optimizing radiotherapy. Herein, we propose a combined functional magnetic resonance imaging approach (blood-oxygen-level-dependent/diffusion-weighted (BOLD/DWI) imaging) for monitoring tumor response to nitric oxide (NO)-induced hypoxic radiosensitiz...
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#1Younghoon Kwon (UCSB: University of California, Santa Barbara)H-Index: 1
#2Justin H. Bernstein (UCSB: University of California, Santa Barbara)
Last. Megan T. Valentine (UCSB: University of California, Santa Barbara)H-Index: 21
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Marine mussels have the remarkable ability to adhere to a variety of natural and artificial surfaces under hostile environmental conditions. Although the molecular composition of mussel adhesives has been well studied, a mechanistic understanding of the physical origins of mussels' impressive adhesive strength remains elusive. Here, we investigated the role of substrate geometry in the adhesive performance of mussels. Experimentally, we created substrates with differing surface properties using ...
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#2Mikhail N. Zharkov (Mordovian State University)H-Index: 7
Last. Pavel A. Karalkin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 6
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Magnetic tissue engineering is one of the rapidly emerging and promising directions of tissue engineering and biofabrication where the magnetic field is employed as temporal removal support or scaffold. Iron oxide nanoparticles are used to label living cells and provide the desired magnetic properties. Recently, polymer microcapsules loaded with iron oxide nanoparticles have been proposed as a novel approach to designing magnetic materials with high local concentrations. These microcapsules can ...
1 CitationsSource
#1Weilu Shen (Harvard University)H-Index: 3
#2Stefan Kalies (MHH: Hannover Medical School)H-Index: 11
Last. Eric Mazur (Harvard University)H-Index: 77
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There is a great need in the biomedical field to efficiently, and cost-effectively, deliver membrane-impermeable molecules into the cellular cytoplasm. However, the cell membrane is a selectively permeable barrier, and large molecules often cannot pass through the phospholipid bilayer. We show that nanosecond laser-activated polymer surfaces of commercial polyvinyl tape and black polystyrene Petri dishes can transiently permeabilize cells for high-throughput, diverse cargo delivery of sizes of u...
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#1Carolina Montoya (TU: Temple University)H-Index: 7
#2Julia Kurylec (TU: Temple University)
Last. Santiago Orrego (TU: Temple University)H-Index: 8
view all 6 authors...
Candida-associated denture stomatitis is a recurring disease affecting up to 67% of denture wearers. Poly(methyl methacrylate) (PMMA) remains the main material employed in the fabrication of dentures due to its desirable physical, mechanical, and aesthetic properties. However, the improvement of its antimicrobial properties remains a challenge. To address this need, we developed PMMA composite filled with piezoelectric nanoparticles of barium titanate (BaTiO3) for therapeutic effects. Candida al...
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#1Yosuke Mizuno (University of Tsukuba)H-Index: 3
#2Tetsushi Taguchi (National Institute for Materials Science)H-Index: 24
Cerebrospinal fluid (CSF) leakage from the dura mater during craniotomy is a common complication, which is associated with infection, meningitis, pneumocephalus, and delayed wound healing. In the present study, we developed an absorbable fish gelatin-based anti-inflammatory sealant for dura mater sealing to prevent CSF leakage. Gelatin derived from Alaska pollock (ApGltn) was modified with α-linolenic acid (ALA), an omega-3 fatty acid that exhibits anti-inflammatory properties, and cross-linked ...
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Natural materials developed in complex architectures that comprise hard and soft phases often display extraordinary mechanical properties, such as the combination of high strength and toughness. Besides the structural arrangements, residual stress is ubiquitous in those materials. Although evidence shows its significant role in the functionalities and properties of the composites, good or bad, residual stress is not fully understood and utilized. In this study, we show through extensive numerica...
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Self-healing hydrogels
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Biomedical engineering
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